RAG2

Gene Symbol	RAG2
Entrez Gene	5897
Alt Symbol	RAG-2
Species	Human
Gene Type	protein-coding
Description	recombination activating gene 2
Other Description	V(D)J recombination-activating protein 2
Swissprots	P55895 Q8TBL4 A8K9E9
Accessions	AAG38705 CCO13799 EAW68117 P55895 AF080577 AAC35287 AK292664 BAF85353 AW058148 BC022397 AAH22397 BM457214 BM463455 DB124002 DB142398 DB143931 DB146077 DB151960 DB165259 DQ892012 ABM82938 DQ895201 ABM86127 S78372 NM_000536 NP_000527 NM_001243785 NP_001230714 NM_001243786 NP_001230715 NR_033666
Function	Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process le
Subcellular Location	Nucleus {ECO:0000250}.
Tissue Specificity	Cells of the B- and T-lymphocyte lineages.
Top Pathways	Primary immunodeficiency

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RAG-2 (C-19) - sc-7623 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RAG-2 (D-20) - sc-34271 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RAG-2 (L-20) - sc-34272 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RAG-2 (M-300) - sc-5600 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-RAG2 antibody - ab189835 from Abcam Prices $378.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 antibody - ab72962 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-RAG2 antibody - ab122956 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 antibody [4D5] - ab96486 from Abcam Prices $376.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4D5

Anti-RAG2 antibody - C-terminal - ab170641 from Abcam Prices $384.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody - LS-C334173 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (aa271-527) - LS-C186092 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (aa348-377) - LS-C162420 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (Internal) - LS-C210176 from LifeSpan Bioscience Prices $295.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (aa348-377, AP) - LS-C284958 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (aa348-377, APC) - LS-C284959 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (aa348-377, Biotin) - LS-C284960 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (aa348-377, Azide-free, HRP) - LS-C284962 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (aa348-377, PE) - LS-C284963 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (C-Terminus) - LS-C145992 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (clone 4D5) - LS-C109145 from LifeSpan Bioscience Prices $320.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4D5

Anti-RAG2 / RAG-2 Antibody (aa348-377) - LS-C324510 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody - LS-C341675 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RAG2 / RAG-2 Antibody (clone EPRAGR239) - LS-C152293 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPRAGR239

Anti-RAG2 / RAG-2 Antibody (clone 2G8) - LS-C198057 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2G8

Anti-RAG2 / RAG-2 Antibody (C-Terminus) - LS-C210174 from LifeSpan Bioscience Prices $295.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

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