| Gene Symbol |
ECSIT
|
| Entrez Gene |
51295
|
| Alt Symbol |
SITPEC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ECSIT signalling integrator
|
| Other Description |
ECSIT homolog|evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial|likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved
|
| Swissprots |
E9PAN9 Q9NYI1 Q96HQ7 Q9BQ95 K7EMM0
|
| Accessions |
EAW84223 Q9BQ95 AF243044 AAF62100 AI336311 AI743680 AK314905 BC000193 AAH00193 BC005119 AAH05119 BC008279 AAH08279 BE791936 BU186092 CR457204 CAG33485 R46579 NM_001142464 NP_001135936 NM_001142465 NP_001135937 NM_001243204 NP_001230133 NM_016581 NP_057665
|
| Function |
Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17344420}. Nucleus {ECO:0000269|PubMed:17344420}. Mitochondrion {ECO:0000269|PubMed:17344420}.
|
| Top Pathways |
MAPK signaling pathway
|
