Gene Symbol | ECSIT |
---|---|
Entrez Gene | 51295 |
Alt Symbol | SITPEC |
Species | Human |
Gene Type | protein-coding |
Description | ECSIT signalling integrator |
Other Description | ECSIT homolog|evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial|likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved |
Swissprots | E9PAN9 Q9NYI1 Q96HQ7 Q9BQ95 K7EMM0 |
Accessions | EAW84223 Q9BQ95 AF243044 AAF62100 AI336311 AI743680 AK314905 BC000193 AAH00193 BC005119 AAH05119 BC008279 AAH08279 BE791936 BU186092 CR457204 CAG33485 R46579 NM_001142464 NP_001135936 NM_001142465 NP_001135937 NM_001243204 NP_001230133 NM_016581 NP_057665 |
Function | Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17344420}. Nucleus {ECO:0000269|PubMed:17344420}. Mitochondrion {ECO:0000269|PubMed:17344420}. |
Top Pathways | MAPK signaling pathway |