Gene Symbol | ECSIT |
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Entrez Gene | 51295 |
Alt Symbol | SITPEC |
Species | Human |
Gene Type | protein-coding |
Description | ECSIT signalling integrator |
Other Description | ECSIT homolog|evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial|likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved |
Swissprots | E9PAN9 Q9NYI1 Q96HQ7 Q9BQ95 K7EMM0 |
Accessions | EAW84223 Q9BQ95 AF243044 AAF62100 AI336311 AI743680 AK314905 BC000193 AAH00193 BC005119 AAH05119 BC008279 AAH08279 BE791936 BU186092 CR457204 CAG33485 R46579 NM_001142464 NP_001135936 NM_001142465 NP_001135937 NM_001243204 NP_001230133 NM_016581 NP_057665 |
Function | Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17344420}. Nucleus {ECO:0000269|PubMed:17344420}. Mitochondrion {ECO:0000269|PubMed:17344420}. |
Top Pathways | MAPK signaling pathway |
ECSIT CRISPR/Cas9 KO Plasmid (h) - sc-403684 from Santa Cruz Biotechnology
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ECSIT HDR Plasmid (h) - sc-403684-HDR from Santa Cruz Biotechnology
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ECSIT Double Nickase Plasmid (h) - sc-403684-NIC from Santa Cruz Biotechnology
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ECSIT Double Nickase Plasmid (h2) - sc-403684-NIC-2 from Santa Cruz Biotechnology
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ECSIT CRISPR Activation Plasmid (h) - sc-403684-ACT from Santa Cruz Biotechnology
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ECSIT CRISPR Activation Plasmid (h2) - sc-403684-ACT-2 from Santa Cruz Biotechnology
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ECSIT Lentiviral Activation Particles (h) - sc-403684-LAC from Santa Cruz Biotechnology
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ECSIT Lentiviral Activation Particles (h2) - sc-403684-LAC-2 from Santa Cruz Biotechnology
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ECSIT siRNA (h) - sc-77224 from Santa Cruz Biotechnology
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ECSIT shRNA Plasmid (h) - sc-77224-SH from Santa Cruz Biotechnology
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ECSIT shRNA (h) Lentiviral Particles - sc-77224-V from Santa Cruz Biotechnology
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ECSIT RNAi - H00051295-R01 from Novus Biologicals
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MISSION® esiRNA - EHU059841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7640 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7640 from Sigma-Aldrich
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ECSIT siRNA (Human) - CRH9672 from Cohesion Biosciences
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ECSIT - MBS8240442 from MyBioSource
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shRNA set against Human ECSIT (NM_016581.4) - SHH283009 from Creative biogene
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Human ECSIT siRNA - orb270174 from Biorbyt
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ECSIT shRNA Plasmid (Human) - CHH9672 from Cohesion Biosciences
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ECSIT miRNA 3'UTR clone - MiUTR3H-09968 from Creative biogene
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ECSIT miRNA 3'UTR clone - MiUTR3H-09969 from Creative biogene
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