MEN1

Gene Symbol MEN1
Entrez Gene 4221
Alt Symbol MEAI, SCG2
Species Human
Gene Type protein-coding
Description multiple endocrine neoplasia I
Other Description menin
Swissprots A5HBC9 Q9BUK2 A5HBC8 A5HBD0 A5HBD2 A5HBC6 Q9BUF0 O00255 A5HBD1 O00632 A5HBC7
Accessions AAC51229 AAC51230 AAP57625 AAP74572 ABQ12621 ABQ12622 ABQ12623 ABQ12624 ABQ12625 ABQ12626 ABQ12627 ACV53846 AEW16337 EAW74303 EAW74304 EAW74305 EAW74306 EAW74307 EAW74308 EAW74309 EAW74310 EAW74311 EAW74312 EAW74313 EAW74314 EAW74315 O00255 AA877856 AJ297485 CAC14129 AJ297486 CAC14130 AJ297487 CAC14131 AJ297488 CAC14132 AJ297489 CAC14133 BC002544 AAH02544 BC002664 AAH02664 BE267140 DQ890757 ABM81683 U93236 AAC51228 Y12338 CAA73007 XM_005274001 XP_005274058 XM_011545040 XP_011543342 XM_011545041 XP_011543343 XM_011545042 XP_011543344 NM_000244 NP_000235 NM_130799 NP_570711 NM_130800 NP_570712 NM_130801 NP_570713 NM_130802 NP_570714 NM_130803 NP_570715 NM_130804 NP_570716
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. {ECO:0000250, ECO:0000269|PubMed:11274402, ECO:0000269|PubMed:11526476, ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:12874027, ECO:0000269|PubMed:14992727}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12874027}. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
Tissue Specificity Ubiquitous.
Top Pathways Transcriptional misregulation in cancer

Menin (D45B1) XP ® Rabbit mAb - 6891 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D45B1
Western blot analysis of extracts from various cell lines using Menin (D45B1) XP ® Rabbit mAb.

Menin (E-8) - sc-376596 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Menin (E-8): sc-376596. Western blot analysis of Menin expression in K-562 (A) and Jurkat (B) nuclear extracts.

Menin (E-9) - sc-390345 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Menin (E-9): sc-390345. Western blot analysis of Menin expression in K-562 (A), Jurkat (B) and A-431 (C) nuclear extracts.

Menin (N-19) - sc-8201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Menin (N-19): sc-8201. Western blot analysis of Menin expression in phorbol-induced Jurkat (A), K-562 (B) and A-431 (C) nuclear extracts.

Menin (B-9) - sc-374371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Menin (B-9): sc-374371. Western blot analysis of Menin expression in K-562 (A) and Jurkat (B) nuclear extracts.

Menin (C-19) - sc-8200 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Menin (C-19) PE: sc-8200 PE. Intracellular FCM analysis of fixed and permeabilized A431 cells. Black line histogram represents the isotype control, normal goat IgG: sc-3992.

Menin (H-300) - sc-5566 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Menin (H-300): sc-5566. Western blot analysis of Menin expression in K-562 nuclear extract.

Anti-Menin antibody - ab75924 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Menin antibody (ab75924) at 1/50 dilution + Ramos cell line lysates at 35 µg

Anti-Menin antibody - ab75923 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Menin antibody (ab75923) at 1/50 dilution + Ramos cell line lysates at 35 µg

Anti-Menin antibody - ab11894 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Menin antibody (Agarose) - ab19206 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Menin antibody [EPR3986] - ab92443 from Abcam

Prices $388.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3986
All lanes : Anti-Menin antibody [EPR3986] (ab92443) at 1/10000 dilutionLane 1 : Jurkat cell lysateLane 2 : 293T cell lysateLane 3 : K-562 cell lysateLane 4 : A431 cell lysateLane 5 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Menin antibody - ChIP Grade - ab31902 from Abcam

Prices $384.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Menin antibody - ChIP Grade (ab31902) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lane 4 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate (ab7902)Lysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-MEN1 / Menin Antibody (aa599-615) - LS-C3126 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MEN1 / Menin Antibody (aa128-144) - LS-C3127 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MEN1 / Menin Antibody - LS-C37354 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-MEN1 / Menin Antibody - LS-C48719 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MEN1 / Menin Antibody (C-Terminus) - LS-C72422 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MEN1 / Menin Antibody - LS-C72425 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MEN1 / Menin Antibody (C-Terminus, Agarose) - LS-C72426 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MEN1 / Menin Antibody (C-Terminus) - LS-C72423 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-MEN1 / Menin Antibody - LS-C72424 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MEN1 / Menin Antibody (aa575-615) - LS-C122122 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MEN1 / Menin Antibody (aa3-32, AP) - LS-C215778 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MEN1 / Menin Antibody (aa3-32, APC) - LS-C215779 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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