MEN1

Gene Symbol	MEN1
Entrez Gene	4221
Alt Symbol	MEAI, SCG2
Species	Human
Gene Type	protein-coding
Description	multiple endocrine neoplasia I
Other Description	menin
Swissprots	A5HBC9 Q9BUK2 A5HBC8 A5HBD0 A5HBD2 A5HBC6 Q9BUF0 O00255 A5HBD1 O00632 A5HBC7
Accessions	AAC51229 AAC51230 AAP57625 AAP74572 ABQ12621 ABQ12622 ABQ12623 ABQ12624 ABQ12625 ABQ12626 ABQ12627 ACV53846 AEW16337 EAW74303 EAW74304 EAW74305 EAW74306 EAW74307 EAW74308 EAW74309 EAW74310 EAW74311 EAW74312 EAW74313 EAW74314 EAW74315 O00255 AA877856 AJ297485 CAC14129 AJ297486 CAC14130 AJ297487 CAC14131 AJ297488 CAC14132 AJ297489 CAC14133 BC002544 AAH02544 BC002664 AAH02664 BE267140 DQ890757 ABM81683 U93236 AAC51228 Y12338 CAA73007 XM_005274001 XP_005274058 XM_011545040 XP_011543342 XM_011545041 XP_011543343 XM_011545042 XP_011543344 NM_000244 NP_000235 NM_130799 NP_570711 NM_130800 NP_570712 NM_130801 NP_570713 NM_130802 NP_570714 NM_130803 NP_570715 NM_130804 NP_570716
Function	Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. {ECO:0000250, ECO:0000269|PubMed:11274402, ECO:0000269|PubMed:11526476, ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:12874027, ECO:0000269|PubMed:14992727}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12874027}. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
Tissue Specificity	Ubiquitous.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Menin full length protein - ab152527 from Abcam Category Protein Source Wheat germ Species Human

Human Menin peptide - ab32961 from Abcam Category Peptide

Human Menin protein fragment - ab152528 from Abcam Category Protein Source Wheat germ Species Human

Menin full length protein - ab114387 from Abcam Category Protein Source Wheat germ

MEN1 / Menin Antibody Blocking Peptide - LS-E2671 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MEN1 / Menin Antibody Blocking Peptide - LS-E8934 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MEN1 / Menin Antibody Blocking Peptide - LS-E8935 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MEN1 / Menin Antibody Blocking Peptide - LS-E13239 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Menin Protein - H00004221-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Menin Protein - H00004221-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Menin Protein - H00004221-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MEN1-Antibody-N-term-Blocking-peptide - BP13747a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MEN1-Antibody-T594-Blocking-Peptide - BP7415b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MEN1-Antibody-S128-Blocking-Peptide - BP7415a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MEN1 peptide - orb217598 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Menin Blocking Peptide - abx062929 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Monkey

Menin - H00004221-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Menin - H00004221-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Menin - H00004221-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Menin - H00004221-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Menin - H00004221-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Menin - H00004221-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Menin - H00004221-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MEN1 fusion protein - Ag7566 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MEN1 fusion protein - ag7253 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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