MEN1
| Gene Symbol | MEN1 |
|---|---|
| Entrez Gene | 4221 |
| Alt Symbol | MEAI, SCG2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | multiple endocrine neoplasia I |
| Other Description | menin |
| Swissprots | A5HBC9 Q9BUK2 A5HBC8 A5HBD0 A5HBD2 A5HBC6 Q9BUF0 O00255 A5HBD1 O00632 A5HBC7 |
| Accessions | AAC51229 AAC51230 AAP57625 AAP74572 ABQ12621 ABQ12622 ABQ12623 ABQ12624 ABQ12625 ABQ12626 ABQ12627 ACV53846 AEW16337 EAW74303 EAW74304 EAW74305 EAW74306 EAW74307 EAW74308 EAW74309 EAW74310 EAW74311 EAW74312 EAW74313 EAW74314 EAW74315 O00255 AA877856 AJ297485 CAC14129 AJ297486 CAC14130 AJ297487 CAC14131 AJ297488 CAC14132 AJ297489 CAC14133 BC002544 AAH02544 BC002664 AAH02664 BE267140 DQ890757 ABM81683 U93236 AAC51228 Y12338 CAA73007 XM_005274001 XP_005274058 XM_011545040 XP_011543342 XM_011545041 XP_011543343 XM_011545042 XP_011543344 NM_000244 NP_000235 NM_130799 NP_570711 NM_130800 NP_570712 NM_130801 NP_570713 NM_130802 NP_570714 NM_130803 NP_570715 NM_130804 NP_570716 |
| Function | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. {ECO:0000250, ECO:0000269|PubMed:11274402, ECO:0000269|PubMed:11526476, ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:12874027, ECO:0000269|PubMed:14992727}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12874027}. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Transcriptional misregulation in cancer |
Menin CRISPR/Cas9 KO Plasmid (h) - sc-402759 from Santa Cruz Biotechnology
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Menin HDR Plasmid (h) - sc-402759-HDR from Santa Cruz Biotechnology
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Menin Double Nickase Plasmid (h) - sc-402759-NIC from Santa Cruz Biotechnology
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Menin Double Nickase Plasmid (h2) - sc-402759-NIC-2 from Santa Cruz Biotechnology
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Menin CRISPR Activation Plasmid (h) - sc-402759-ACT from Santa Cruz Biotechnology
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Menin CRISPR Activation Plasmid (h2) - sc-402759-ACT-2 from Santa Cruz Biotechnology
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Menin Lentiviral Activation Particles (h) - sc-402759-LAC from Santa Cruz Biotechnology
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Menin Lentiviral Activation Particles (h2) - sc-402759-LAC-2 from Santa Cruz Biotechnology
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Menin siRNA (h) - sc-35922 from Santa Cruz Biotechnology
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Menin shRNA Plasmid (h) - sc-35922-SH from Santa Cruz Biotechnology
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Menin shRNA (h) Lentiviral Particles - sc-35922-V from Santa Cruz Biotechnology
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Menin RNAi - H00004221-R05 from Novus Biologicals
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Menin RNAi - H00004221-R04 from Novus Biologicals
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Menin RNAi - H00004221-R07 from Novus Biologicals
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Menin RNAi - H00004221-R03 from Novus Biologicals
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Menin RNAi - H00004221-R06 from Novus Biologicals
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Menin RNAi - H00004221-R02 from Novus Biologicals
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MISSION® esiRNA - EHU067451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1387 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1388 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1388 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1387 from Sigma-Aldrich
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MEN1 siRNA (Human) - CRH2870 from Cohesion Biosciences
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Menin RNAi - H00004221-R01 from Novus Biologicals
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Human MEN1 siRNA - orb263372 from Biorbyt
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