MEN1

Gene Symbol MEN1
Entrez Gene 4221
Alt Symbol MEAI, SCG2
Species Human
Gene Type protein-coding
Description multiple endocrine neoplasia I
Other Description menin
Swissprots A5HBC9 Q9BUK2 A5HBC8 A5HBD0 A5HBD2 A5HBC6 Q9BUF0 O00255 A5HBD1 O00632 A5HBC7
Accessions AAC51229 AAC51230 AAP57625 AAP74572 ABQ12621 ABQ12622 ABQ12623 ABQ12624 ABQ12625 ABQ12626 ABQ12627 ACV53846 AEW16337 EAW74303 EAW74304 EAW74305 EAW74306 EAW74307 EAW74308 EAW74309 EAW74310 EAW74311 EAW74312 EAW74313 EAW74314 EAW74315 O00255 AA877856 AJ297485 CAC14129 AJ297486 CAC14130 AJ297487 CAC14131 AJ297488 CAC14132 AJ297489 CAC14133 BC002544 AAH02544 BC002664 AAH02664 BE267140 DQ890757 ABM81683 U93236 AAC51228 Y12338 CAA73007 XM_005274001 XP_005274058 XM_011545040 XP_011543342 XM_011545041 XP_011543343 XM_011545042 XP_011543344 NM_000244 NP_000235 NM_130799 NP_570711 NM_130800 NP_570712 NM_130801 NP_570713 NM_130802 NP_570714 NM_130803 NP_570715 NM_130804 NP_570716
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. {ECO:0000250, ECO:0000269|PubMed:11274402, ECO:0000269|PubMed:11526476, ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:12874027, ECO:0000269|PubMed:14992727}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12874027}. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
Tissue Specificity Ubiquitous.
Top Pathways Transcriptional misregulation in cancer

MEN1-Over-expression-Lysate - LY12881a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag MEN1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MEN1 gene

MEN1 293T Cell Transient Overexpression Lysate(Denatured) - H00004221-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

Menin Overexpression Lysate (Denatured) - H00004221-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
MEN1 transfected lysate.

Menin Overexpression Lysate (Native) - NBP2-05738 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: Menin Overexpression Lysate (Adult Normal) [NBP2-05738] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Menin.

Panoply™ Human MEN1 Knockdown Stable Cell Line - CSC-DC009402 from Creative biogene

Category Cell Line
Species Human

Human MEN1 Knockout Cell Line-HeLa - CSC-RT0758 from Creative biogene

Category Cell Line
Species Human

MEN1 KO Cell Lysate-HeLa - CLKO-0262 from Creative biogene

Category Cell Lysate
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