MEN1

Gene Symbol MEN1
Entrez Gene 4221
Alt Symbol MEAI, SCG2
Species Human
Gene Type protein-coding
Description multiple endocrine neoplasia I
Other Description menin
Swissprots A5HBC9 Q9BUK2 A5HBC8 A5HBD0 A5HBD2 A5HBC6 Q9BUF0 O00255 A5HBD1 O00632 A5HBC7
Accessions AAC51229 AAC51230 AAP57625 AAP74572 ABQ12621 ABQ12622 ABQ12623 ABQ12624 ABQ12625 ABQ12626 ABQ12627 ACV53846 AEW16337 EAW74303 EAW74304 EAW74305 EAW74306 EAW74307 EAW74308 EAW74309 EAW74310 EAW74311 EAW74312 EAW74313 EAW74314 EAW74315 O00255 AA877856 AJ297485 CAC14129 AJ297486 CAC14130 AJ297487 CAC14131 AJ297488 CAC14132 AJ297489 CAC14133 BC002544 AAH02544 BC002664 AAH02664 BE267140 DQ890757 ABM81683 U93236 AAC51228 Y12338 CAA73007 XM_005274001 XP_005274058 XM_011545040 XP_011543342 XM_011545041 XP_011543343 XM_011545042 XP_011543344 NM_000244 NP_000235 NM_130799 NP_570711 NM_130800 NP_570712 NM_130801 NP_570713 NM_130802 NP_570714 NM_130803 NP_570715 NM_130804 NP_570716
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. {ECO:0000250, ECO:0000269|PubMed:11274402, ECO:0000269|PubMed:11526476, ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:12874027, ECO:0000269|PubMed:14992727}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12874027}. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
Tissue Specificity Ubiquitous.
Top Pathways Transcriptional misregulation in cancer

Goat anti-Menin Antibody, Affinity Purified - PLA0027 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Menin (MEN1), Human, ELISA Kit - CSB-EL013694HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

MEN1 (Human) IP-WB Antibody Pair - H00004221-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

multiple endocrine neoplasia I, ELISA Kit - MBS942430 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human MEN1 is typically less than 7.03 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 28.12 pg/ml -1800 pg/ml.

Human Menin(MEN1) ELISA kit - CSB-EL013694HU from Cusabio

Category ELISA Kit
Sensitivity 7.03 pg/ml
Range 28.12 pg/ml-1800 pg/ml

Human Menin (MEN1) ELISA Kit - EKC34590 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 7.03 pg/ml
Range 28.12 pg/ml-1800 pg/ml

Human MEN1 ELISA Kit - E025148 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human MEN1 is typically less than 7.03 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

anti-Menin antibody - ARG10827 from Arigo Biolaboratories

Category ELISA Kit

MEN1 ELISA Kit (Human) (OKCA01357) - OKCA01357 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 7.03 pg/mL
Range 28.12 - 1,800 pg/mL

Human Menin (MEN1) ELISA Kit - AE33771HU from ARP American Research Products

Category ELISA Kit
Prices $549.00
Sizes 96 t

Human MEN1 ELISA Kit - orb404821 from Biorbyt

Category ELISA Kit
Sensitivity 7.03 pg/ml
Range 28.12 pg/ml-1800 pg/ml
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