| Gene Symbol |
DEDD
|
| Entrez Gene |
9191
|
| Alt Symbol |
CASP8IP1, DEDD1, DEFT, FLDED1, KE05
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
death effector domain containing
|
| Other Description |
DEDPro1|FLDED-1|death effector domain-containing protein|death effector domain-containing testicular molecule
|
| Swissprots |
O60737 D3DVF5 O75618
|
| Accessions |
EAW52648 EAW52649 EAW52650 EAW52651 EAW52652 EAW52653 O75618 AF043733 AAC80280 AF064605 AAC17110 AF083236 AAC33105 AF100341 AAD16414 AJ010973 CAA09445 AK001497 AK022531 BAG51086 AK296629 BAG59233 BC013910 AAH13910 BC016724 AAH16724 BG565440 CR536556 CAG38793 JF432647 ADZ15864 XM_005245597 XP_005245654 XM_005245598 XP_005245655 XM_005245599 XP_005245656 XM_005245600 XP_005245657 NM_001039711 NP_001034800 NM_001039712 NP_001034801 NM_032998 NP_127491 NM_004216
|
| Function |
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with highest levels in testis. {ECO:0000269|PubMed:9832420}.
|