DEDD
| Gene Symbol | DEDD |
|---|---|
| Entrez Gene | 9191 |
| Alt Symbol | CASP8IP1, DEDD1, DEFT, FLDED1, KE05 |
| Species | Human |
| Gene Type | protein-coding |
| Description | death effector domain containing |
| Other Description | DEDPro1|FLDED-1|death effector domain-containing protein|death effector domain-containing testicular molecule |
| Swissprots | O60737 D3DVF5 O75618 |
| Accessions | EAW52648 EAW52649 EAW52650 EAW52651 EAW52652 EAW52653 O75618 AF043733 AAC80280 AF064605 AAC17110 AF083236 AAC33105 AF100341 AAD16414 AJ010973 CAA09445 AK001497 AK022531 BAG51086 AK296629 BAG59233 BC013910 AAH13910 BC016724 AAH16724 BG565440 CR536556 CAG38793 JF432647 ADZ15864 XM_005245597 XP_005245654 XM_005245598 XP_005245655 XM_005245599 XP_005245656 XM_005245600 XP_005245657 NM_001039711 NP_001034800 NM_001039712 NP_001034801 NM_032998 NP_127491 NM_004216 |
| Function | A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. {ECO:0000250}. |
| Tissue Specificity | Widely expressed with highest levels in testis. {ECO:0000269|PubMed:9832420}. |
DEDD CRISPR/Cas9 KO Plasmid (h) - sc-405952 from Santa Cruz Biotechnology
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DEDD HDR Plasmid (h) - sc-405952-HDR from Santa Cruz Biotechnology
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DEDD Double Nickase Plasmid (h) - sc-405952-NIC from Santa Cruz Biotechnology
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DEDD Double Nickase Plasmid (h2) - sc-405952-NIC-2 from Santa Cruz Biotechnology
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DEDD CRISPR Activation Plasmid (h) - sc-405952-ACT from Santa Cruz Biotechnology
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DEDD CRISPR Activation Plasmid (h2) - sc-405952-ACT-2 from Santa Cruz Biotechnology
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DEDD Lentiviral Activation Particles (h) - sc-405952-LAC from Santa Cruz Biotechnology
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DEDD Lentiviral Activation Particles (h2) - sc-405952-LAC-2 from Santa Cruz Biotechnology
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DEDD siRNA (h) - sc-37383 from Santa Cruz Biotechnology
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DEDD shRNA Plasmid (h) - sc-37383-SH from Santa Cruz Biotechnology
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DEDD shRNA (h) Lentiviral Particles - sc-37383-V from Santa Cruz Biotechnology
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DEDD RNAi - H00009191-R03 from Novus Biologicals
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DEDD RNAi - H00009191-R01 from Novus Biologicals
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MISSION® esiRNA - EHU031141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7079 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7079 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08409 from Sigma-Aldrich
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DEDD siRNA (Human) - CRH6083 from Cohesion Biosciences
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DEDD RNAi - H00009191-R02 from Novus Biologicals
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DEDD - MBS8231488 from MyBioSource
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shRNA set against Human DEDD (NM_001039711.1) - SHH276285 from Creative biogene
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shRNA set against Human DEDD(NM_001039711.1) - SHG227845 from Creative biogene
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shRNA set against Human DEDD(NM_032998.2) - SHG227931 from Creative biogene
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Human DEDD siRNA - orb266585 from Biorbyt
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DEDD shRNA Plasmid (Human) - CHH6083 from Cohesion Biosciences
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