DEDD

Gene Symbol	DEDD
Entrez Gene	9191
Alt Symbol	CASP8IP1, DEDD1, DEFT, FLDED1, KE05
Species	Human
Gene Type	protein-coding
Description	death effector domain containing
Other Description	DEDPro1|FLDED-1|death effector domain-containing protein|death effector domain-containing testicular molecule
Swissprots	O60737 D3DVF5 O75618
Accessions	EAW52648 EAW52649 EAW52650 EAW52651 EAW52652 EAW52653 O75618 AF043733 AAC80280 AF064605 AAC17110 AF083236 AAC33105 AF100341 AAD16414 AJ010973 CAA09445 AK001497 AK022531 BAG51086 AK296629 BAG59233 BC013910 AAH13910 BC016724 AAH16724 BG565440 CR536556 CAG38793 JF432647 ADZ15864 XM_005245597 XP_005245654 XM_005245598 XP_005245655 XM_005245599 XP_005245656 XM_005245600 XP_005245657 NM_001039711 NP_001034800 NM_001039712 NP_001034801 NM_032998 NP_127491 NM_004216
Function	A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. {ECO:0000250}.
Tissue Specificity	Widely expressed with highest levels in testis. {ECO:0000269|PubMed:9832420}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DEDD overexpression lysate - LY409798 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DEDD overexpression lysate - LY421814 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DEDD overexpression lysate - LY421815 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DEDD overexpression lysate - LY425659 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DEDD 293 Cell Lysate - 409568 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

DEDD 293 Cell Lysate - 405085 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

DEDD Overexpression Lysate (Native) - NBL1-09815 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DEDD Overexpression Lysate (Native) - NBP2-08530 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DEDD Overexpression Lysate (Native) - NBP2-09207 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DEDD Overexpression Lysate (Native) - NBL1-09814 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DEDD Over-expression Lysate Product - GWB-B8CCC3 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

DEDD Over-expression Lysate Product - GWB-8612B0 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human DEDD Knockdown Stable Cell Line - CSC-DC004177 from Creative biogene Category Cell Line Species Human

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