| Gene Symbol |
CPB2
|
| Entrez Gene |
1361
|
| Alt Symbol |
CPU, PCPB, TAFI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carboxypeptidase B2 (plasma)
|
| Other Description |
carboxypeptidase B-like protein|carboxypeptidase B2|carboxypeptidase B2 (plasma, carboxypeptidase U)|carboxypeptidase R|thrombin-activable fibrinolysis inhibitor|thrombin-activatable fibrinolysis inhibitor
|
| Swissprots |
Q5T9K1 Q96IY4 Q15114 A8K464 Q5T9K2 Q9P2Y6
|
| Accessions |
AAT97987 EAX08754 EAX08755 Q96IY4 AA700377 AB011969 BAA90475 AK290829 BAF83518 AU100156 AV719308 BC007057 AAH07057 BT006936 AAP35582 DQ890567 ABM92184 EU176478 ABW03279 M75106 AAA60042 NM_001278541 NP_001265470 NM_001872 NP_001863 NM_016413
|
| Function |
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:10574983}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Plasma; synthesized in the liver.
|
| Top Pathways |
Complement and coagulation cascades, Protein digestion and absorption, Pancreatic secretion
|