Gene Symbol | CPB2 |
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Entrez Gene | 1361 |
Alt Symbol | CPU, PCPB, TAFI |
Species | Human |
Gene Type | protein-coding |
Description | carboxypeptidase B2 (plasma) |
Other Description | carboxypeptidase B-like protein|carboxypeptidase B2|carboxypeptidase B2 (plasma, carboxypeptidase U)|carboxypeptidase R|thrombin-activable fibrinolysis inhibitor|thrombin-activatable fibrinolysis inhibitor |
Swissprots | Q5T9K1 Q96IY4 Q15114 A8K464 Q5T9K2 Q9P2Y6 |
Accessions | AAT97987 EAX08754 EAX08755 Q96IY4 AA700377 AB011969 BAA90475 AK290829 BAF83518 AU100156 AV719308 BC007057 AAH07057 BT006936 AAP35582 DQ890567 ABM92184 EU176478 ABW03279 M75106 AAA60042 NM_001278541 NP_001265470 NM_001872 NP_001863 NM_016413 |
Function | Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:10574983}. |
Subcellular Location | Secreted. |
Tissue Specificity | Plasma; synthesized in the liver. |
Top Pathways | Complement and coagulation cascades, Protein digestion and absorption, Pancreatic secretion |
Active human Carboxypeptidase B2 full length protein - ab81749 from Abcam
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Human Carboxypeptidase B2 full length protein - ab158190 from Abcam
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Human Carboxypeptidase B2 peptide - ab88171 from Abcam
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Human Carboxypeptidase B2 protein fragment - ab158191 from Abcam
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CPB2 / TAFI Antibody Blocking Peptide - LS-E16032 from LifeSpan Bioscience
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CPB2 / TAFI Antibody Blocking Peptide - LS-E8272 from LifeSpan Bioscience
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Recombinant Human Carboxypeptidase B2/CPB2 Protein - H00001361-Q01 from Novus Biologicals
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Carboxypeptidase B2/CPB2 Recombinant Protein - H00001361-P01 from Novus Biologicals
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CPB2-Antibody-Center-E134-Blocking-Peptide - BP6541c from Abgent, a WuXi AppTec company
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TAFI Protein (OPMA04295) - OPMA04295 from Aviva Systems Biology
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TAFI protein - orb82212 from Biorbyt
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TAFI protein - orb79690 from Biorbyt
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Carboxypeptidase B2 Blocking Peptide - 33R-8190 from Fitzgerald
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Human TAFI Protein - abx060746 from Abbexa
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Human TAFI Protein - abx069267 from Abbexa
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Carboxypeptidase B2 - H00001361-P01-10 from Acris Antibodies
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Carboxypeptidase B2 - H00001361-P01-25 from Acris Antibodies
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Carboxypeptidase B2 - H00001361-Q01-10 from Acris Antibodies
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Carboxypeptidase B2 - H00001361-Q01-25 from Acris Antibodies
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Carboxypeptidase B2 - 8TA1 from Acris Antibodies
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TAFI - MD-17-0055P from RayBiotech
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Thrombin Activatable Fibrinolysis Inhibitor (TAFI), Human - 20-6897 from ARP American Research Products
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CPB2 fusion protein - ag1110 from Proteintech Group
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Carboxypeptidase B2 Peptide - 350565 from ABBIOTEC
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Recombinant Human CPB2, His tagged - CPB2-3210H from Creative Biomart
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