SNAI2

Gene Symbol	SNAI2
Entrez Gene	6591
Alt Symbol	SLUG, SLUGH1, SNAIL2, WS2D
Species	Human
Gene Type	protein-coding
Description	snail family zinc finger 2
Other Description	neural crest transcription factor SLUG|protein snail homolog 2|slug (chicken homolog), zinc finger protein|snail homolog 2|zinc finger protein SNAI2
Swissprots	O43623 Q53FC1 B2R6P6
Accessions	AAC34288 AAD55240 EAW86700 O43623 AA410443 AK223368 BAD97088 AK312661 BAG35543 BC014890 AAH14890 BC015895 AAH15895 BG706203 DA522147 EU446862 ABZ92391 U97060 AAB58705 NM_003068 NP_003059
Function	Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulat
Subcellular Location	Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Tissue Specificity	Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level). {ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}.
Top Pathways	Adherens junction, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Snail homolog 2, SNAI2, Human, ELISA Kit - CSB-E11753h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Zinc finger protein SNAI2, SNAI2, Human, ELISA Kit - E2412h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

SNAI2 (Human) IP-WB Antibody Pair - H00006591-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

snail homolog 2 (Drosophila) , ELISA Kit - MBS704660 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human SNAI2 is typically less than 7.81 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 pg/ml -2000 pg/ml.

human snail homolog 2,SNAI2 ELISA Kit - CSB-E11753h from Cusabio Category ELISA Kit Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Bovine SNAI2 / SLUG ELISA Kit (Custom ELISA) - LS-F19753 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse SNAI2 / SLUG ELISA Kit (Custom ELISA) - LS-F19754 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human SNAI2 / SLUG ELISA Kit (Custom ELISA) - LS-F19755 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat SNAI2 / SLUG ELISA Kit (Custom ELISA) - LS-F19752 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Snail Homolog 2 ELISA Kit - abx052444 from Abbexa Category ELISA Kit

SNAI2 - EKH4440 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human SNAI2 ELISA Kit - E035557 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human SNAI2 is typically less than 7.81 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

SNAI2 ELISA Kit (Human) (OKEH05165) - OKEH05165 from Aviva Systems Biology Category ELISA Kit Prices $440.00 Sizes 96 wells Sensitivity 0.078 ng/mL Range 0.156-10 ng/mL

anti-Slug antibody - ARG55242 from Arigo Biolaboratories Category ELISA Kit

anti-Slug antibody - ARG54888 from Arigo Biolaboratories Category ELISA Kit

anti-Slug antibody - ARG54927 from Arigo Biolaboratories Category ELISA Kit

Zinc finger protein SNAI2, ELISA Kit - MBS764633 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Zinc finger protein SNAI2, ELISA Kit - MBS2885338 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

SNAI2 ELISA Kit (Human) (OKCA02309) - OKCA02309 from Aviva Systems Biology Category ELISA Kit Sensitivity 7.81 pg/mL Range 31.25 - 2,000 pg/mL

Human SNAI2 / SLUG ELISA Kit (Sandwich ELISA) - LS-F33786 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.156-10 ng/ml

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