SNAI2

Gene Symbol	SNAI2
Entrez Gene	6591
Alt Symbol	SLUG, SLUGH1, SNAIL2, WS2D
Species	Human
Gene Type	protein-coding
Description	snail family zinc finger 2
Other Description	neural crest transcription factor SLUG|protein snail homolog 2|slug (chicken homolog), zinc finger protein|snail homolog 2|zinc finger protein SNAI2
Swissprots	O43623 Q53FC1 B2R6P6
Accessions	AAC34288 AAD55240 EAW86700 O43623 AA410443 AK223368 BAD97088 AK312661 BAG35543 BC014890 AAH14890 BC015895 AAH15895 BG706203 DA522147 EU446862 ABZ92391 U97060 AAB58705 NM_003068 NP_003059
Function	Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulat
Subcellular Location	Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Tissue Specificity	Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level). {ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}.
Top Pathways	Adherens junction, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SLUG CRISPR/Cas9 KO Plasmid (h) - sc-400389 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SLUG HDR Plasmid (h) - sc-400389-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SLUG Double Nickase Plasmid (h) - sc-400389-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SLUG Double Nickase Plasmid (h2) - sc-400389-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SLUG CRISPR Activation Plasmid (h) - sc-400389-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SLUG CRISPR Activation Plasmid (h2) - sc-400389-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SLUG Lentiviral Activation Particles (h) - sc-400389-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SLUG Lentiviral Activation Particles (h2) - sc-400389-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SLUG siRNA (h) - sc-38393 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SLUG shRNA Plasmid (h) - sc-38393-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SLUG shRNA (h) Lentiviral Particles - sc-38393-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU048191 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1310 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1310 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08508 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08508

SNAI2 siRNA (Human) - CRH4477 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Slug RNAi - H00006591-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SNAI2 - MBS8222530 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SNAI2 (NM_003068.4) - SHH413836 from Creative biogene Category siRNA Species Reactivities Human

SLUG CRISPR/Cas9 KO Plasmid (h2) - sc-400389-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SLUG HDR Plasmid (h2) - sc-400389-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Human SNAI2 siRNA - orb264979 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SNAI2 shRNA Plasmid (Human) - CHH4477 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SNAI2 miRNA 3'UTR clone - MiUTR3H-04710 from Creative biogene Species Reactivities Human

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