SNAI2

Gene Symbol	SNAI2
Entrez Gene	6591
Alt Symbol	SLUG, SLUGH1, SNAIL2, WS2D
Species	Human
Gene Type	protein-coding
Description	snail family zinc finger 2
Other Description	neural crest transcription factor SLUG|protein snail homolog 2|slug (chicken homolog), zinc finger protein|snail homolog 2|zinc finger protein SNAI2
Swissprots	O43623 Q53FC1 B2R6P6
Accessions	AAC34288 AAD55240 EAW86700 O43623 AA410443 AK223368 BAD97088 AK312661 BAG35543 BC014890 AAH14890 BC015895 AAH15895 BG706203 DA522147 EU446862 ABZ92391 U97060 AAB58705 NM_003068 NP_003059
Function	Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulat
Subcellular Location	Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Tissue Specificity	Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level). {ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}.
Top Pathways	Adherens junction, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLUG full length protein - ab159541 from Abcam Category Protein Source Wheat germ Species Human

Human SLUG full length protein - ab201878 from Abcam Category Protein Source E. coli Species Human

Human SLUG peptide - ab27840 from Abcam Category Peptide

Human SLUG protein fragment - ab114212 from Abcam Category Protein Source Wheat germ Species Human

SNAI2 / SLUG Antibody Blocking Peptide - LS-E6835 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNAI2 / SLUG Antibody Blocking Peptide - LS-E30279 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SNAI2 / SLUG Antibody Blocking Peptide - LS-E30280 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SNAI2 / SLUG Antibody Blocking Peptide - LS-E11742 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Slug Partial Recombinant Protein - H00006591-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Slug Recombinant Protein - H00006591-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Slug Peptide - NBP1-76733PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Slug Peptide - NBP1-76403PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Slug Peptide - P0850 from Novus Biologicals Category Peptide Species Human

SLUG-Antibody-N-term-K9-Blocking-Peptide - BP2053b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SLUG-Antibody-Center-Blocking-Peptide - BP2053a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SNAI2 protein - 80R-4216 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

SLUG Blocking Peptide - abx064208 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig, Sheep

SNAI2 / SLUG (1-268, His-tag) - AR51898PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SNAI2 / SLUG (1-268, His-tag) - AR51898PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

SNAI2 / SLUG - H00006591-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SNAI2 / SLUG - H00006591-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SNAI2 / SLUG - H00006591-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SNAI2 / SLUG Control Peptide - AP30812CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SNAI2 / SLUG Control Peptide - AP30813CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Slug Peptide - 3959P from ProSci Category Peptide Species Human

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