SNAI2
| Gene Symbol | SNAI2 |
|---|---|
| Entrez Gene | 6591 |
| Alt Symbol | SLUG, SLUGH1, SNAIL2, WS2D |
| Species | Human |
| Gene Type | protein-coding |
| Description | snail family zinc finger 2 |
| Other Description | neural crest transcription factor SLUG|protein snail homolog 2|slug (chicken homolog), zinc finger protein|snail homolog 2|zinc finger protein SNAI2 |
| Swissprots | O43623 Q53FC1 B2R6P6 |
| Accessions | AAC34288 AAD55240 EAW86700 O43623 AA410443 AK223368 BAD97088 AK312661 BAG35543 BC014890 AAH14890 BC015895 AAH15895 BG706203 DA522147 EU446862 ABZ92391 U97060 AAB58705 NM_003068 NP_003059 |
| Function | Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulat |
| Subcellular Location | Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions. |
| Tissue Specificity | Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level). {ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}. |
| Top Pathways | Adherens junction, Hippo signaling pathway |
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