SNAI2

Gene Symbol	SNAI2
Entrez Gene	6591
Alt Symbol	SLUG, SLUGH1, SNAIL2, WS2D
Species	Human
Gene Type	protein-coding
Description	snail family zinc finger 2
Other Description	neural crest transcription factor SLUG|protein snail homolog 2|slug (chicken homolog), zinc finger protein|snail homolog 2|zinc finger protein SNAI2
Swissprots	O43623 Q53FC1 B2R6P6
Accessions	AAC34288 AAD55240 EAW86700 O43623 AA410443 AK223368 BAD97088 AK312661 BAG35543 BC014890 AAH14890 BC015895 AAH15895 BG706203 DA522147 EU446862 ABZ92391 U97060 AAB58705 NM_003068 NP_003059
Function	Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulat
Subcellular Location	Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Tissue Specificity	Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level). {ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}.
Top Pathways	Adherens junction, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Slug (C19G7) Rabbit mAb - 9585 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C19G7

Slug (L40C6) Mouse mAb - 9589 from Cell Signaling Technology Host Mouse Clonality Monoclonal Clone L40C6

SLUG (A-7) - sc-166476 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SLUG (C-7) - sc-166902 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SLUG (D-19) - sc-10437 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SLUG (G-18) - sc-10436 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SLUG (H-140) - sc-15391 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-SLUG antibody - ab38551 from Abcam Host Rabbit Clonality Polyclonal

Anti-SLUG antibody - ab106077 from Abcam Prices $387.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLUG antibody - ab75629 from Abcam Prices $304.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLUG antibody - ab183760 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SLUG antibody - ab62589 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLUG antibody [1G7] - ab128485 from Abcam Prices $384.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1G7

Anti-SLUG antibody [mAbcam51772] (FITC) - ab150214 from Abcam Prices $359.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone mAbcam51772

Anti-SNAIL + SLUG (phospho S246) antibody - ab63568 from Abcam Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SNAIL + SLUG antibody - ab85936 from Abcam Prices $382.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SNAIL + SLUG antibody [20C8] - ab78105 from Abcam Prices $378.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 20C8

Anti-SNAI2 / SLUG Antibody (clone 1A6) - LS-C175161 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1A6

Anti-SNAI2 / SLUG Antibody - LS-C75880 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-SNAI2 / SLUG Antibody (aa97-169) - LS-C126304 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SNAI2 / SLUG Antibody (clone 3F4) - LS-C139528 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F4

Anti-SNAI2 / SLUG Antibody (aa82-100) - LS-C149024 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SNAI2 / SLUG Antibody (aa1-30) - LS-C97982 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SNAI2 / SLUG Antibody (clone 2H5) - LS-C109151 from LifeSpan Bioscience Prices $345.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2H5

Anti-SNAI2 / SLUG Antibody (clone 2E10) - LS-C139527 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2E10

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