| Gene Symbol |
NEK9
|
| Entrez Gene |
91754
|
| Alt Symbol |
NERCC, NERCC1, Nek8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NIMA-related kinase 9
|
| Other Description |
NIMA (never in mitosis gene a)- related kinase 9|NIMA-related kinase Nek8|nercc1 kinase|never in mitosis A-related kinase 9|nimA-related kinase 8|nimA-related protein kinase 9|serine/threonine-protein kinase Nek9
|
| Swissprots |
Q8NCN0 Q8TD19 Q9Y6S5 Q9UPI4 Q8TCY4 Q52LK6 Q9Y6S6 Q9Y6S4
|
| Accessions |
AAD31936 AAD31938 AAD31939 AAD31940 EAW81220 EAW81221 EAW81222 Q8TD19 AB082526 BAC02704 AK128693 BAG54712 AL117502 AL832633 AL833036 AY048580 AAL05428 AY080896 AAL87410 BC001714 AAH01714 BC009336 AAH09336 BC093881 AAH93881 BC112101 AAI12102 BM976692 DB455229 XM_005268208 XP_005268265 XM_005268209 XP_005268266 NM_033116 NP_149107
|
| Function |
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. {ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:14660563}. Nucleus {ECO:0000269|PubMed:14660563}.
|
| Tissue Specificity |
Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts.
|