Gene Symbol | NEK9 |
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Entrez Gene | 91754 |
Alt Symbol | NERCC, NERCC1, Nek8 |
Species | Human |
Gene Type | protein-coding |
Description | NIMA-related kinase 9 |
Other Description | NIMA (never in mitosis gene a)- related kinase 9|NIMA-related kinase Nek8|nercc1 kinase|never in mitosis A-related kinase 9|nimA-related kinase 8|nimA-related protein kinase 9|serine/threonine-protein kinase Nek9 |
Swissprots | Q8NCN0 Q8TD19 Q9Y6S5 Q9UPI4 Q8TCY4 Q52LK6 Q9Y6S6 Q9Y6S4 |
Accessions | AAD31936 AAD31938 AAD31939 AAD31940 EAW81220 EAW81221 EAW81222 Q8TD19 AB082526 BAC02704 AK128693 BAG54712 AL117502 AL832633 AL833036 AY048580 AAL05428 AY080896 AAL87410 BC001714 AAH01714 BC009336 AAH09336 BC093881 AAH93881 BC112101 AAI12102 BM976692 DB455229 XM_005268208 XP_005268265 XM_005268209 XP_005268266 NM_033116 NP_149107 |
Function | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. {ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14660563}. Nucleus {ECO:0000269|PubMed:14660563}. |
Tissue Specificity | Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts. |
Active human NEK9 protein fragment - ab125614 from Abcam
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Active human NEK9 protein fragment - ab196083 from Abcam
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Human NEK9 full length protein - ab132199 from Abcam
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Human NEK9 protein fragment - ab153569 from Abcam
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NEK9 Antibody Blocking Peptide - LS-E3292 from LifeSpan Bioscience
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NEK9 Antibody Blocking Peptide - LS-E17717 from LifeSpan Bioscience
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NEK9 Antibody Blocking Peptide - LS-E9476 from LifeSpan Bioscience
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NEK9 Antibody Blocking Peptide - LS-E29235 from LifeSpan Bioscience
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NEK9 Antibody Blocking Peptide - LS-E29296 from LifeSpan Bioscience
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NEK9 Antibody Blocking Peptide - LS-E29297 from LifeSpan Bioscience
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Recombinant Human NEK9 Protein - H00091754-Q01 from Novus Biologicals
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Recombinant Human NEK9 Protein - H00091754-P01 from Novus Biologicals
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NEK9 Peptide - P3075 from Novus Biologicals
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NEK9-Antibody-C-term-Blocking-Peptide - BP8079b from Abgent, a WuXi AppTec company
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NEK9 blocking peptide - GTX89356-PEP from GeneTex
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NEK9 Blocking Peptide - 33R-3280 from Fitzgerald
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NEK9 - H00091754-P01-10 from Acris Antibodies
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NEK9 - H00091754-P01-25 from Acris Antibodies
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NEK9 - H00091754-Q01-10 from Acris Antibodies
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NEK9 - H00091754-Q01-25 from Acris Antibodies
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NEK9 - P5613 from Acris Antibodies
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NEK9 fusion protein - Ag1689 from Proteintech Group
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NEK9 fusion protein - ag1678 from Proteintech Group
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NEK9, Active Human Recombinant Protein - GWB-PSA505 from Genway Biotech
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Recombinant Human NEK9, GST-tagged - NEK9-1259H from Creative Biomart
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