Gene Symbol | NEK9 |
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Entrez Gene | 91754 |
Alt Symbol | NERCC, NERCC1, Nek8 |
Species | Human |
Gene Type | protein-coding |
Description | NIMA-related kinase 9 |
Other Description | NIMA (never in mitosis gene a)- related kinase 9|NIMA-related kinase Nek8|nercc1 kinase|never in mitosis A-related kinase 9|nimA-related kinase 8|nimA-related protein kinase 9|serine/threonine-protein kinase Nek9 |
Swissprots | Q8NCN0 Q8TD19 Q9Y6S5 Q9UPI4 Q8TCY4 Q52LK6 Q9Y6S6 Q9Y6S4 |
Accessions | AAD31936 AAD31938 AAD31939 AAD31940 EAW81220 EAW81221 EAW81222 Q8TD19 AB082526 BAC02704 AK128693 BAG54712 AL117502 AL832633 AL833036 AY048580 AAL05428 AY080896 AAL87410 BC001714 AAH01714 BC009336 AAH09336 BC093881 AAH93881 BC112101 AAI12102 BM976692 DB455229 XM_005268208 XP_005268265 XM_005268209 XP_005268266 NM_033116 NP_149107 |
Function | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. {ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14660563}. Nucleus {ECO:0000269|PubMed:14660563}. |
Tissue Specificity | Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts. |
Nek9 CRISPR/Cas9 KO Plasmid (h) - sc-404971 from Santa Cruz Biotechnology
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Nek9 HDR Plasmid (h) - sc-404971-HDR from Santa Cruz Biotechnology
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Nek9 Double Nickase Plasmid (h) - sc-404971-NIC from Santa Cruz Biotechnology
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Nek9 Double Nickase Plasmid (h2) - sc-404971-NIC-2 from Santa Cruz Biotechnology
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Nek9 CRISPR Activation Plasmid (h) - sc-404971-ACT from Santa Cruz Biotechnology
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Nek9 CRISPR Activation Plasmid (h2) - sc-404971-ACT-2 from Santa Cruz Biotechnology
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Nek9 Lentiviral Activation Particles (h) - sc-404971-LAC from Santa Cruz Biotechnology
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Nek9 Lentiviral Activation Particles (h2) - sc-404971-LAC-2 from Santa Cruz Biotechnology
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Nek9 siRNA (h) - sc-61178 from Santa Cruz Biotechnology
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Nek9 shRNA Plasmid (h) - sc-61178-SH from Santa Cruz Biotechnology
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Nek9 shRNA (h) Lentiviral Particles - sc-61178-V from Santa Cruz Biotechnology
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NEK9 RNAi - H00091754-R03 from Novus Biologicals
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MISSION® esiRNA - EHU012191 from Sigma-Aldrich
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MISSION® siRNA - SIHK1415 from Sigma-Aldrich
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MISSION® siRNA - SIHK1416 from Sigma-Aldrich
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MISSION® siRNA - SIHK1414 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15205 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15205 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01786 from Sigma-Aldrich
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NEK9 siRNA (Human) - CRJ4077 from Cohesion Biosciences
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shRNA set against Human NEK9 (NM_033116.4) - SHH351308 from Creative biogene
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Human NEK9 siRNA - orb274578 from Biorbyt
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NEK9 shRNA Plasmid (Human) - CHJ4077 from Cohesion Biosciences
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NEK9 miRNA 3'UTR clone - MiUTR4H-TG05954 from Creative biogene
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