Gene Symbol | MSL1 |
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Entrez Gene | 339287 |
Alt Symbol | MSL-1, hMSL1 |
Species | Human |
Gene Type | protein-coding |
Description | male-specific lethal 1 homolog (Drosophila) |
Other Description | MSL1-like 1|male-specific lethal 1 homolog|male-specific lethal 1-like 1|male-specific lethal-1 homolog 1 |
Swissprots | Q69Z03 Q0VF46 Q68DK7 |
Accessions | Q68DK7 AK055378 AK124185 AK125654 BAG54229 AK297619 BAG59995 AL049450 CAH10734 BC039449 BC118997 AAI18998 BC122543 AAI22544 BX647188 CR749360 CAH18213 EU831932 ACE87373 EU832027 ACE86689 R23466 XM_005257298 XP_005257355 XM_005257299 XP_005257356 XM_011524740 XP_011523042 NM_001012241 NP_001012241 |
Function | Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15561718}. |
MSL-1 (C-16) - sc-168659 from Santa Cruz Biotechnology
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MSL-1 (Q-19) - sc-168661 from Santa Cruz Biotechnology
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Anti-MSL1 antibody - ab121718 from Abcam
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Anti-MSL1 antibody - ab121762 from Abcam
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Anti-MSL1 antibody - ab123272 from Abcam
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Anti-MSL1 Antibody (aa339-367, AP) - LS-C237818 from LifeSpan Bioscience
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Anti-MSL1 Antibody (aa339-367, Biotin) - LS-C237819 from LifeSpan Bioscience
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Anti-MSL1 Antibody (aa339-367, APC) - LS-C237820 from LifeSpan Bioscience
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Anti-MSL1 Antibody (aa339-367, FITC) - LS-C237821 from LifeSpan Bioscience
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Anti-MSL1 Antibody (aa339-367, Azide-free, HRP) - LS-C248856 from LifeSpan Bioscience
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Anti-MSL1 Antibody (aa338-367) - LS-C323132 from LifeSpan Bioscience
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Anti-MSL1 Antibody (aa339-367, PE) - LS-C237822 from LifeSpan Bioscience
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Anti-MSL1 Antibody (aa118-167) - LS-C151707 from LifeSpan Bioscience
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Anti-MSL1 Antibody (aa339-367) - LS-C164650 from LifeSpan Bioscience
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MSL1 Antibody - NBP1-90506 from Novus Biologicals
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MSL1 Antibody - NBP1-90505 from Novus Biologicals
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ANTI-MSL1 (CENTER) antibody produced in rabbit - SAB1306806 from Sigma-Aldrich
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Anti-MSL1 antibody produced in rabbit - HPA022800 from Sigma-Aldrich
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Anti-MSL1 antibody produced in rabbit - HPA023567 from Sigma-Aldrich
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MSL1 antibody - middle region (ARP64394_P050) - ARP64394_P050 from Aviva Systems Biology
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MSL1-Antibody-Center - AP14386c from Abgent, a WuXi AppTec company
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MSL1 Antibody - middle region (OAAB10684) - OAAB10684 from Aviva Systems Biology
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MSL1 Antibody - abx028019 from Abbexa
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MSL1 antibody - 24373-1-AP from Acris Antibodies
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MSL1 antibody - H00339287-B01P from Acris Antibodies
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