MSL1

Gene Symbol MSL1
Entrez Gene 339287
Alt Symbol MSL-1, hMSL1
Species Human
Gene Type protein-coding
Description male-specific lethal 1 homolog (Drosophila)
Other Description MSL1-like 1|male-specific lethal 1 homolog|male-specific lethal 1-like 1|male-specific lethal-1 homolog 1
Swissprots Q69Z03 Q0VF46 Q68DK7
Accessions Q68DK7 AK055378 AK124185 AK125654 BAG54229 AK297619 BAG59995 AL049450 CAH10734 BC039449 BC118997 AAI18998 BC122543 AAI22544 BX647188 CR749360 CAH18213 EU831932 ACE87373 EU832027 ACE86689 R23466 XM_005257298 XP_005257355 XM_005257299 XP_005257356 XM_011524740 XP_011523042 NM_001012241 NP_001012241
Function Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15561718}.

MSL-1 CRISPR/Cas9 KO Plasmid (h) - sc-415510 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MSL-1 HDR Plasmid (h) - sc-415510-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MSL-1 Double Nickase Plasmid (h) - sc-415510-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MSL-1 Double Nickase Plasmid (h2) - sc-415510-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MSL-1 CRISPR Activation Plasmid (h) - sc-415510-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MSL-1 CRISPR Activation Plasmid (h2) - sc-415510-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MSL-1 Lentiviral Activation Particles (h) - sc-415510-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MSL-1 Lentiviral Activation Particles (h2) - sc-415510-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN14649 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14649 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MSL1 siRNA (Human) - CRJ7279 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MSL1 (NM_001012241.1) - SHH345696 from Creative biogene

Category siRNA
Species Reactivities Human

Human MSL1 siRNA - orb277780 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MSL1 shRNA Plasmid (Human) - CHJ7279 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MSL1 miRNA 3'UTR clone - MiUTR1H-06479 from Creative biogene

Species Reactivities Human
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