| Gene Symbol |
MSL1
|
| Entrez Gene |
339287
|
| Alt Symbol |
MSL-1, hMSL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
male-specific lethal 1 homolog (Drosophila)
|
| Other Description |
MSL1-like 1|male-specific lethal 1 homolog|male-specific lethal 1-like 1|male-specific lethal-1 homolog 1
|
| Swissprots |
Q69Z03 Q0VF46 Q68DK7
|
| Accessions |
Q68DK7 AK055378 AK124185 AK125654 BAG54229 AK297619 BAG59995 AL049450 CAH10734 BC039449 BC118997 AAI18998 BC122543 AAI22544 BX647188 CR749360 CAH18213 EU831932 ACE87373 EU832027 ACE86689 R23466 XM_005257298 XP_005257355 XM_005257299 XP_005257356 XM_011524740 XP_011523042 NM_001012241 NP_001012241
|
| Function |
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15561718}.
|