MSL1

Gene Symbol	MSL1
Entrez Gene	339287
Alt Symbol	MSL-1, hMSL1
Species	Human
Gene Type	protein-coding
Description	male-specific lethal 1 homolog (Drosophila)
Other Description	MSL1-like 1|male-specific lethal 1 homolog|male-specific lethal 1-like 1|male-specific lethal-1 homolog 1
Swissprots	Q69Z03 Q0VF46 Q68DK7
Accessions	Q68DK7 AK055378 AK124185 AK125654 BAG54229 AK297619 BAG59995 AL049450 CAH10734 BC039449 BC118997 AAI18998 BC122543 AAI22544 BX647188 CR749360 CAH18213 EU831932 ACE87373 EU832027 ACE86689 R23466 XM_005257298 XP_005257355 XM_005257299 XP_005257356 XM_011524740 XP_011523042 NM_001012241 NP_001012241
Function	Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15561718}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-MSL1-cDNA-Clone - DC14250 from Abgent, a WuXi AppTec company Prices $473.85 Sizes 10 µg Species Human Accession BC122543

MSL1 - MBS1266911 from MyBioSource Species Human Accession BC122543

Human MSL1 Gene ORF cDNA clone in cloning vector - HG15841-G from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15841-ACG from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15841-NY from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15841-ACR from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15841-ANR from Sino Biological Species Human

Human MSL1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-tagged - HG15841-NH from Sino Biological Species Human Accession BC122543

Human MSL1 Gene ORF cDNA clone expression plasmid, C-His tag - HG15841-CH from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15841-NF from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15841-CY from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15841-CF from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15841-ANG from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid - HG15841-UT from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15841-CM from Sino Biological Species Human

Human MSL1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15841-NM from Sino Biological Species Human

Human MSL1 ORF clone (NM_001012241.1) - CDCL134607 from Creative biogene Species Human

Human MSL1 ORF Clone (BC122543) - CDCS406479 from Creative biogene Species Human Accession Q68DK7

Human MSL1 ORF clone (BC122543) - CDCB157733 from Creative biogene Species Human

Human MSL1 cDNA Clone(NM_001012241.1) - CDFH011797 from Creative biogene Species Human

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