| Gene Symbol | DR1 |
|---|---|
| Entrez Gene | 1810 |
| Alt Symbol | NC2, NC2-BETA |
| Species | Human |
| Gene Type | protein-coding |
| Description | down-regulator of transcription 1, TBP-binding (negative cofactor 2) |
| Other Description | TATA-binding protein-associated phosphoprotein|negative cofactor 2-beta|protein Dr1 |
| Swissprots | Q01658 |
| Accessions | EAW73072 EAW73073 EAW73074 EAW73075 EAW73076 Q01658 AK057541 BAG51931 AK223442 BAD97162 AK311288 AL137673 AL833729 CAH56250 BC002809 AAH02809 BC035507 AAH35507 BC068553 AAH68553 BT006972 AAP35618 M97388 AAA58442 NM_001938 NP_001929 |
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
| Subcellular Location | Nucleus. |
down-regulator of transcription 1, TBP-binding (negative cofactor 2) , ELISA Kit - MBS9342952 from MyBioSource
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Human DR1 ELISA Kit - E012370 from Biobool
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