| Gene Symbol |
DR1
|
| Entrez Gene |
1810
|
| Alt Symbol |
NC2, NC2-BETA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
|
| Other Description |
TATA-binding protein-associated phosphoprotein|negative cofactor 2-beta|protein Dr1
|
| Swissprots |
Q01658
|
| Accessions |
EAW73072 EAW73073 EAW73074 EAW73075 EAW73076 Q01658 AK057541 BAG51931 AK223442 BAD97162 AK311288 AL137673 AL833729 CAH56250 BC002809 AAH02809 BC035507 AAH35507 BC068553 AAH68553 BT006972 AAP35618 M97388 AAA58442 NM_001938 NP_001929
|
| Function |
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}.
|
| Subcellular Location |
Nucleus.
|
