| Gene Symbol |
SCG5
|
| Entrez Gene |
6447
|
| Alt Symbol |
7B2, P7B2, SGNE1, SgV
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
secretogranin V
|
| Other Description |
neuroendocrine protein 7B2|pituitary polypeptide|prohormone convertase chaperone|secretogranin V (7B2 protein)|secretogranin-5|secretory granule endocrine protein I|secretory granule, neuroendocrine protein 1 (7B2 protein)
|
| Swissprots |
Q9BS38 Q6FHD0 P01164 P05408
|
| Accessions |
CAB90397 EAW92261 EAW92262 EAW92263 P05408 AK314965 BC005349 AAH05349 BC093053 AAH93053 BP377248 CR541824 CAG46623 Y00757 CAA68726 XM_005254595 XP_005254652 XM_005254596 XP_005254653 XM_011548932 XP_011547234 XM_011548933 XP_011547235 NM_001144757 NP_001138229 NM_003020 NP_003011
|
| Function |
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269|PubMed:7913882}.
|
| Subcellular Location |
Secreted. Note=Neuroendocrine and endocrine secretory granules.
|
