SCG5

Gene Symbol SCG5
Entrez Gene 6447
Alt Symbol 7B2, P7B2, SGNE1, SgV
Species Human
Gene Type protein-coding
Description secretogranin V
Other Description neuroendocrine protein 7B2|pituitary polypeptide|prohormone convertase chaperone|secretogranin V (7B2 protein)|secretogranin-5|secretory granule endocrine protein I|secretory granule, neuroendocrine protein 1 (7B2 protein)
Swissprots Q9BS38 Q6FHD0 P01164 P05408
Accessions CAB90397 EAW92261 EAW92262 EAW92263 P05408 AK314965 BC005349 AAH05349 BC093053 AAH93053 BP377248 CR541824 CAG46623 Y00757 CAA68726 XM_005254595 XP_005254652 XM_005254596 XP_005254653 XM_011548932 XP_011547234 XM_011548933 XP_011547235 NM_001144757 NP_001138229 NM_003020 NP_003011
Function Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269|PubMed:7913882}.
Subcellular Location Secreted. Note=Neuroendocrine and endocrine secretory granules.

Sg V (C-16) - sc-69236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sg V (C-16): sc-69236. Western blot analysis of Sg V expression in non-transfected 293T: sc-117752 (A) and mouse Sg V transfected 293T: sc-127531 (B) whole cell lysates.

Sg V (P-19) - sc-69238 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sg V (P-19): sc-69238. Western blot analysis of Sg V expression in non-transfected: sc-117752 (A) and mouse Sg V transfected: sc-127531 (B) 293T whole cell lysates.

Sg V (Y-16) - sc-69239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sg V (Y-16): sc-69239. Western blot analysis of Sg V expression in K-562 (A), Jurkat (B), MIA PaCa-2 (C) and HeLa (D) whole cell lysates.

Anti-Secretogranin V antibody - ab22699 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab75197 (1µg/ml) staining secretogranin V in human pancreas using an automated system (DAKO Autostainer Plus). Using this protocol there is strong cytoplasmic staining of Islets of Langerhans.Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffer citrate pH 6.0 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

Anti-Secretogranin V antibody - ab55687 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55687 Secretogranin V antibody at 1ug/ml.

Anti-Secretogranin V antibody - ab128267 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Secretogranin V antibody (ab128267) at 1 µg/ml + Human fetal heart lysate at 10 µg

Anti-SCG5 / 7B2 Antibody (clone 8G11) - LS-C198183 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8G11
Detection limit for recombinant GST tagged SCG5 is 3 ng/ml as a capture antibody.

Anti-SCG5 / 7B2 Antibody (aa183-212) - LS-C162893 from LifeSpan Bioscience

Prices $250.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of SCG5 Antibody (C-term) in K562 cell line lysates (35 ug/lane). SCG5 (arrow) was detected using the purified Pab.

Anti-SCG5 / 7B2 Antibody (aa126-159) - LS-C144175 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SCG5 / 7B2 Antibody (aa126-159) - LS-C144176 from LifeSpan Bioscience

Prices $740.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-SCG5 / 7B2 Antibody (aa59-160) - LS-C126252 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SCG5 / 7B2 Antibody - LS-C341006 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCG5 / 7B2 Antibody (aa70-119) - LS-C151560 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SCG5 / 7B2 antibody Western Blot of Jurkat.

Anti-SCG5 / 7B2 Antibody (C-Terminus) - LS-C151559 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SCG5 / 7B2 antibody Western Blot of Fetal Heart.

Secretogranin V Antibody - NBP1-90312 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Secretogranin V Antibody [NBP1-90312] - Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in islet cells.

Secretogranin V Antibody (8G11) - H00006447-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8G11
Sandwich ELISA: Secretogranin V Antibody (8G11) [H00006447-M02] - Detection limit for recombinant GST tagged SCG5 is 3 ng/ml as a capture antibody.

Secretogranin-5 Polyclonal Antibody - bs-10762R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Mouse spleen lysate probed with Rabbit Anti-Secretogranin-5 Polyclonal Antibody, Unconjugated (bs-10762R) at 1:300 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:5000 for 90min at 37˚C.

Monoclonal Anti-SGNE1 antibody produced in mouse - WH0006447M2 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8G11
<B>Immunoblotting</B><BR/>Monoclonal Anti-SGNE1, <B>Cat. No. WH0006447M2</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.22 kDa using immunogen protein lysate.

Anti-SCG5 antibody produced in rabbit - HPA013136 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SCG5: <B>Cat. No. HPA013136</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human pancreas shows strong cytoplasmic positivity in islet cells.

SCG5 antibody - C-terminal region (ARP63846_P050) - ARP63846_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SCG5 antibody - N-terminal region (ARP63847_P050) - ARP63847_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SCG5 antibody - 70R-20105 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Secretogranin-5 (SCG5) antibody - 10761-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Mouse brain were subjected to SDS PAGE followed by western blot with 10761-1-AP(SCG5 Antibody) at dilution of 1:1000

Secretogranin-5 (SCG5) antibody - H00006447-M02 from Acris Antibodies

Prices $360.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8G11

SCG5 antibody - STJ28230 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
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