| Gene Symbol |
APPL1
|
| Entrez Gene |
26060
|
| Alt Symbol |
APPL, DIP13alpha
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
|
| Other Description |
AKT2 interactor|DCC-interacting protein 13-alpha|adapter protein containing PH domain, PTB domain and leucine zipper motif 1|adaptor protein containing pH domain, PTB domain and leucine zipper motif 1|dip13-alpha|signaling adaptor protein DIP13alpha
|
| Swissprots |
Q9P2B9 Q9UKG1
|
| Accessions |
EAW65335 EAW65336 Q9UKG1 AB037849 BAA92666 AF169797 AAF04012 AF424738 AAL17835 AK299008 BAG61090 AK310716 BC010911 BC028599 AAH28599 JF432301 ADZ15518 XM_011533583 XP_011531885 NM_012096 NP_036228
|
| Function |
Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. {ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378}.
|
| Subcellular Location |
Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
|
| Tissue Specificity |
High levels in heart, ovary, pancreas and skeletal muscle. {ECO:0000269|PubMed:10490823}.
|
| Top Pathways |
Colorectal cancer
|
