APPL1

Gene Symbol APPL1
Entrez Gene 26060
Alt Symbol APPL, DIP13alpha
Species Human
Gene Type protein-coding
Description adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Other Description AKT2 interactor|DCC-interacting protein 13-alpha|adapter protein containing PH domain, PTB domain and leucine zipper motif 1|adaptor protein containing pH domain, PTB domain and leucine zipper motif 1|dip13-alpha|signaling adaptor protein DIP13alpha
Swissprots Q9P2B9 Q9UKG1
Accessions EAW65335 EAW65336 Q9UKG1 AB037849 BAA92666 AF169797 AAF04012 AF424738 AAL17835 AK299008 BAG61090 AK310716 BC010911 BC028599 AAH28599 JF432301 ADZ15518 XM_011533583 XP_011531885 NM_012096 NP_036228
Function Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. {ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378}.
Subcellular Location Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Tissue Specificity High levels in heart, ovary, pancreas and skeletal muscle. {ECO:0000269|PubMed:10490823}.
Top Pathways Colorectal cancer

APPL1 CRISPR/Cas9 KO Plasmid (h) - sc-402243 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APPL1 HDR Plasmid (h) - sc-402243-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APPL1 Double Nickase Plasmid (h) - sc-402243-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APPL1 Double Nickase Plasmid (h2) - sc-402243-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APPL1 CRISPR Activation Plasmid (h) - sc-402243-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APPL1 CRISPR Activation Plasmid (h2) - sc-402243-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APPL1 Lentiviral Activation Particles (h) - sc-402243-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APPL1 Lentiviral Activation Particles (h2) - sc-402243-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APPL1 siRNA (h) - sc-61980 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APPL1 shRNA Plasmid (h) - sc-61980-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APPL1 shRNA (h) Lentiviral Particles - sc-61980-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU050431 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3360 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3360 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

APPL1 siRNA (Human) - CRH8689 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

APPL RNAi - H00026060-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

APPL1 - MBS8207410 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

APPL1 - MBS826804 from MyBioSource

Prices $255.00
Sizes 5 od
Species Reactivities Human

shRNA set against Human APPL1 (NM_012096.2) - SHH238750 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human APPL1(NM_012096.2) - SHG066417 from Creative biogene

Category siRNA
Species Reactivities Human

APPL1 shRNA Plasmid (Human) - CHH8689 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

APPL1 miRNA 3'UTR clone - MiUTR1H-00492 from Creative biogene

Species Reactivities Human
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