APPL1

Gene Symbol APPL1
Entrez Gene 26060
Alt Symbol APPL, DIP13alpha
Species Human
Gene Type protein-coding
Description adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Other Description AKT2 interactor|DCC-interacting protein 13-alpha|adapter protein containing PH domain, PTB domain and leucine zipper motif 1|adaptor protein containing pH domain, PTB domain and leucine zipper motif 1|dip13-alpha|signaling adaptor protein DIP13alpha
Swissprots Q9P2B9 Q9UKG1
Accessions EAW65335 EAW65336 Q9UKG1 AB037849 BAA92666 AF169797 AAF04012 AF424738 AAL17835 AK299008 BAG61090 AK310716 BC010911 BC028599 AAH28599 JF432301 ADZ15518 XM_011533583 XP_011531885 NM_012096 NP_036228
Function Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. {ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378}.
Subcellular Location Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Tissue Specificity High levels in heart, ovary, pancreas and skeletal muscle. {ECO:0000269|PubMed:10490823}.
Top Pathways Colorectal cancer

APPL1 (D83H4) XP ® Rabbit mAb - 3858 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D83H4
Western blot analysis of extracts from various cell types using APPL1 (D83H4) XP ® Rabbit mAb.

APPL1 Antibody - 3276 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HEK293, A20 and PC12 cells using APPL1 Antibody.

APPL1 (E-17) - sc-55063 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
APPL1 (E-17): sc-55063. Western blot analysis of APPL1 expression in PC-12 (A), A-10 (B) and HeLa (C) whole cell lysates and rat skeletal muscle tissue extract (D).

APPL1 (A-1) - sc-271901 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
APPL1 (H-3): sc-271901. Western blot analysis of APPL1 expression in HeLa (A), ES-2 (B), Caki-1 (C), 3T3-L1 (D) and PC-12 (E) whole cell lysates.

APPL1 (H-3) - sc-271909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
APPL1 (H-3): sc-271909. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

APPL1 (H-96) - sc-67402 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
APPL1 (H-96): sc-67402. Western blot analysis of APPL1 expression in 3T3-L1 (A), A-673 (B), A-10 (C) and HeLa (D) whole cell lysates.

APPL1 (N-17) - sc-55065 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
APPL1 (N-17): sc-55065. Western blot analysis of APPL1 expression in PC-12 whole cell lysate.

Anti-APPL antibody - ab95195 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-APPL antibody (ab95195) at 0.2 µg/mlLane 1 : HEK293 cell lysateLane 2 : C2C12 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat anti-rabbit antibody

Anti-APPL antibody - ab167493 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-APPL antibody (ab167493) at 1 µg/mlLane 1 : APPL transfected 293T cell lysate Lane 2 : Non-transfected 293T cell lysate Lysates/proteins at 15 µl per lane.SecondaryGoat anti-Mouse IgG HRP at 1/2500 dilution

Anti-APPL antibody [EPR13569] - ab180140 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13569
Immunofluorescent analysis of 4% paraformaldehyde fixed MCF7 cells labeling APPL with ab180140 at 1/500 dilution. Secondary antibody Goat anti rabbit IgG(Dylight 555) Conterstained with Dapi blue.

Anti-APPL antibody - ab59592 from Abcam

Prices $394.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-APPL antibody (ab59592) at 1/2000 dilutionLane 1 : Mouse neuroblastoma whole cell lysateLane 2 : Mouse neuroblastoma whole cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated Goat anti-rabbit IgG monoclonal at 1/1000 dilution

Anti-APPL antibody - ab112509 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APPL antibody - ab128591 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab128591, at 1/100 dilution, stains human APPL in Formalin/PFA-fixed paraffin-embedded fetal heart tissue by immunohistochemistry

Anti-APPL antibody - ab59119 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-APPL1 / APPL Antibody (aa467-516) IHC-plus™ - LS-B5856 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-APPL1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5856 concentration 5 ug/ml.

Anti-APPL1 / APPL Antibody - LS-C82347 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/ Immunofluorescence - APPL antibody

Anti-APPL1 / APPL Antibody - LS-C126603 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-APPL1 / APPL Antibody (aa145-158) - LS-C54524 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.5 ug/ml) staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL1 adenovirus for 48hrs. Detected by chemiluminescence.

Anti-APPL1 / APPL Antibody (aa697-709) - LS-C186443 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-APPL1 / APPL Antibody - LS-C309487 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APPL1 / APPL Antibody (aa138-158) - LS-C312552 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of APPL1 / APPL antibody. WB: HELA Cell Lysate.

Anti-APPL1 / APPL Antibody (aa111-160) IHC-plus™ - LS-B11430 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-APPL1 / APPL antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11430 concentration 20 ug/ml.

Anti-APPL1 / APPL Antibody (aa502-681) - LS-C179026 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APPL Antibody (709208) - MAB7075 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 709208
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, HEK293 human embryonic kidney cell line, beta TC‑6 mouse beta cell insulinoma cell line, OVCAR‑3 human ovarian carcinoma cell line, and SH‑SY5Y human neuroblastoma cell line. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human APPL Monoclonal Antibody (Catalog # MAB7075) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for APPL at approximately 80 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

APPL Antibody - NBP2-15434 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: APPL Antibody [NBP2-15434] - Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE; antibody diluted at 1:1000.
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