CLC

Gene Symbol CLC
Entrez Gene 1178
Alt Symbol GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN
Species Human
Gene Type protein-coding
Description Charcot-Leyden crystal galectin
Other Description Charcot-Leyden crystal protein|eosinophil lysophospholipase|galectin 10|galectin-10|lectin, galactoside-binding, soluble, 10|lysolecithin acylhydrolase
Swissprots Q0VDE3 C5HZ14 Q05315 C5HZ13
Accessions AAC28912 AAC37530 AAC51157 EAW56914 Q05315 AV715261 AV762486 AW292557 BC119711 AAI19712 BC119712 AAI19713 FJ613334 ACR09636 FJ613335 ACR09637 L01664 AAA36190 NM_001828 NP_001819
Function Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). {ECO:0000269|PubMed:17502455}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:17502455}. Cytoplasmic granule {ECO:0000269|PubMed:17502455}. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
Tissue Specificity Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level). {ECO:0000269|PubMed:17502455, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:19758173, ECO:0000269|PubMed:22880030}.

CLC-Over-expression-Lysate - LY12444a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CLC (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CLC gene

CLC overexpression lysate - LY419729 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

CLC 293 Cell Lysate - 409236 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Galectin-10 Overexpression Lysate (Native) - NBL1-09226 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Galectin 10 Overexpression Lysate (Adult Normal) [NBL1-09226] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Galectin 10.

CLC Over-expression Lysate Product - GWB-C5551B from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human CLC Knockdown Stable Cell Line - CSC-DC003208 from Creative biogene

Category Cell Line
Species Human
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