| Gene Symbol |
CLC
|
| Entrez Gene |
1178
|
| Alt Symbol |
GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Charcot-Leyden crystal galectin
|
| Other Description |
Charcot-Leyden crystal protein|eosinophil lysophospholipase|galectin 10|galectin-10|lectin, galactoside-binding, soluble, 10|lysolecithin acylhydrolase
|
| Swissprots |
Q0VDE3 C5HZ14 Q05315 C5HZ13
|
| Accessions |
AAC28912 AAC37530 AAC51157 EAW56914 Q05315 AV715261 AV762486 AW292557 BC119711 AAI19712 BC119712 AAI19713 FJ613334 ACR09636 FJ613335 ACR09637 L01664 AAA36190 NM_001828 NP_001819
|
| Function |
Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). {ECO:0000269|PubMed:17502455}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:17502455}. Cytoplasmic granule {ECO:0000269|PubMed:17502455}. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
|
| Tissue Specificity |
Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level). {ECO:0000269|PubMed:17502455, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:19758173, ECO:0000269|PubMed:22880030}.
|
