CLC

Gene Symbol CLC
Entrez Gene 1178
Alt Symbol GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN
Species Human
Gene Type protein-coding
Description Charcot-Leyden crystal galectin
Other Description Charcot-Leyden crystal protein|eosinophil lysophospholipase|galectin 10|galectin-10|lectin, galactoside-binding, soluble, 10|lysolecithin acylhydrolase
Swissprots Q0VDE3 C5HZ14 Q05315 C5HZ13
Accessions AAC28912 AAC37530 AAC51157 EAW56914 Q05315 AV715261 AV762486 AW292557 BC119711 AAI19712 BC119712 AAI19713 FJ613334 ACR09636 FJ613335 ACR09637 L01664 AAA36190 NM_001828 NP_001819
Function Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). {ECO:0000269|PubMed:17502455}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:17502455}. Cytoplasmic granule {ECO:0000269|PubMed:17502455}. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
Tissue Specificity Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level). {ECO:0000269|PubMed:17502455, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:19758173, ECO:0000269|PubMed:22880030}.

galectin-10 (D-8) - sc-374395 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
galectin-10 (D-8): sc-374395. Western blot analysis of galectin-10 expression in human PBL whole cell lysate.

galectin-10 (C-15) - sc-69478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
galectin-10 (C-15): sc-69478. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing cytoplasmic and nuclear staining of inflammatory cells.

galectin-10 (H-40) - sc-68426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
galectin-10 (H-40): sc-68426. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing cytoplasmic staining of inflammatory cells.

galectin-10 (N-17) - sc-69481 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

galectin-10 (B-F42) - sc-65318 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
galectin-10 (B-F42): sc-65318. Indirect, intracellular FCM analysis of human peripheral blood leukocytes stained with galectin-10 (B-F42), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Anti-Galectin 10 antibody - ab123426 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Galectin 10 antibody (ab123426) at 1/100 dilutionLane 1 : 293 cell lysate, non-transfectedLane 2 : 293 cell lysate, transiently transfected with Human Galectin 10 geneLysates/proteins at 2 µg per lane.

Anti-Galectin 10 antibody [B-F42] - ab27417 from Abcam

Prices $370.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-F42
ab27417 staining Galectin 10 in human Eosinophil Granulocyte cells by Immunocytochemistry/ Immunofluorescence. The cells were fixed in paraformaldehyde, permeabilised in 0.5% Triton X-100 and then blocked using 10% serum for 30 minutes at 37°C. Samples were then incubated with primary antibody at 1/40 for 1 hour at 37°C. The secondary antibody used was a donkey anti-mouse IgG conjugated to Cy2® used at a 1/200 dilution.

Anti-Galectin 10 antibody [B-F42] - ab47270 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-F42

Anti-Galectin 10 antibody [EPR11197] - ab157475 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11197
All lanes : Anti-Galectin 10 antibody [EPR11197] (ab157475) at 1/10000 dilutionLane 1 : Human spleen lysateLane 2 : Human bone marrow lysateLane 3 : Human tonsil lysateLane 4 : THP-1 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Galectin 10 antibody [EPR11198(B)] - ab156005 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11198(B)
All lanes : Anti-Galectin 10 antibody [EPR11198(B)] (ab156005) at 1/1000 dilutionLane 1 : Human spleen lysateLane 2 : Human bone marrow lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CLC Antibody (aa94-124) - LS-C168802 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of CLC (arrow) using rabbit polyclonal CLC Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CLC gene.

Anti-CLC Antibody (aa94-124, AP) - LS-C221787 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa94-124, APC) - LS-C221788 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa94-124, Biotin) - LS-C221789 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa94-124, FITC) - LS-C221790 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa94-124, Azide-free, HRP) - LS-C221791 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa94-124, PE) - LS-C221792 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa90-119, AP) - LS-C221793 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa90-119, APC) - LS-C221794 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa90-119, Biotin) - LS-C221795 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa90-119, FITC) - LS-C221796 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa90-119, Azide-free, HRP) - LS-C221797 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa90-119, PE) - LS-C221798 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa2-142, Biotin) - LS-C298395 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLC Antibody (aa94-124) - LS-C320410 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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