| Gene Symbol |
ENPP4
|
| Entrez Gene |
22875
|
| Alt Symbol |
NPP4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
|
| Other Description |
AP3A hydrolase|AP3Aase|E-NPP 4|NPP-4|bis(5'-adenosyl)-triphosphatase ENPP4|ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function)|ectonucleotide pyrophosphatase/phosphodiesterase family member 4
|
| Swissprots |
Q9Y6X5 Q7L2N1 A8K5G1
|
| Accessions |
CAJ78397 EAX04292 Q9Y6X5 AB020686 BAA74902 AJ420515 AK291276 BAF83965 BC018054 AAH18054 BI548305 CA433087 DA261977 DQ892332 ABM83258 DQ895537 ABM86463 NM_014936 NP_055751
|
| Function |
Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269|PubMed:22995898, ECO:0000269|PubMed:24338010}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22995898}; Single-pass type I membrane protein {ECO:0000269|PubMed:22995898}.
|
| Tissue Specificity |
Expressed on the surface of vascular endothelia. {ECO:0000269|PubMed:22995898}.
|
| Top Pathways |
Purine metabolism
|