Gene Symbol | ENPP4 |
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Entrez Gene | 22875 |
Alt Symbol | NPP4 |
Species | Human |
Gene Type | protein-coding |
Description | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) |
Other Description | AP3A hydrolase|AP3Aase|E-NPP 4|NPP-4|bis(5'-adenosyl)-triphosphatase ENPP4|ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function)|ectonucleotide pyrophosphatase/phosphodiesterase family member 4 |
Swissprots | Q9Y6X5 Q7L2N1 A8K5G1 |
Accessions | CAJ78397 EAX04292 Q9Y6X5 AB020686 BAA74902 AJ420515 AK291276 BAF83965 BC018054 AAH18054 BI548305 CA433087 DA261977 DQ892332 ABM83258 DQ895537 ABM86463 NM_014936 NP_055751 |
Function | Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269|PubMed:22995898, ECO:0000269|PubMed:24338010}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:22995898}; Single-pass type I membrane protein {ECO:0000269|PubMed:22995898}. |
Tissue Specificity | Expressed on the surface of vascular endothelia. {ECO:0000269|PubMed:22995898}. |
Top Pathways | Purine metabolism |
NPP4 (C-15) - sc-248107 from Santa Cruz Biotechnology
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NPP4 (T-12) - sc-248105 from Santa Cruz Biotechnology
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Anti-ENPP4 antibody - ab121505 from Abcam
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Anti-ENPP4 Antibody (aa171-200, APC) - LS-C246886 from LifeSpan Bioscience
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Anti-ENPP4 Antibody (aa171-200, Biotin) - LS-C246887 from LifeSpan Bioscience
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Anti-ENPP4 Antibody (aa171-200, AP) - LS-C234962 from LifeSpan Bioscience
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Anti-ENPP4 Antibody (aa171-200, FITC) - LS-C246888 from LifeSpan Bioscience
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Anti-ENPP4 Antibody (aa171-200, PE) - LS-C246889 from LifeSpan Bioscience
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Anti-ENPP4 Antibody - LS-C307919 from LifeSpan Bioscience
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Anti-ENPP4 Antibody (aa171-200, Azide-free, HRP) - LS-C249911 from LifeSpan Bioscience
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Anti-ENPP4 Antibody (aa170-200) - LS-C321116 from LifeSpan Bioscience
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Anti-ENPP4 Antibody (aa171-200) - LS-C159532 from LifeSpan Bioscience
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ENPP4 Antibody - NBP1-81466 from Novus Biologicals
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ENPP4 Antibody - H00022875-B01 from Novus Biologicals
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ENPP4 Antibody - H00022875-B01P from Novus Biologicals
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Anti-ENPP4 antibody produced in rabbit - HPA016594 from Sigma-Aldrich
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Anti-ENPP4 antibody produced in mouse - SAB1407155 from Sigma-Aldrich
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ENPP4-Antibody-Center - AP18179c from Abgent, a WuXi AppTec company
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ENPP4 Antibody - middle region (OAAB13673) - OAAB13673 from Aviva Systems Biology
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Anti -ENPP4 (Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 4, NPP4) - 210692 from USBiological Life Science
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Anti -ENPP4 (KIAA0879, NPP4, Ectonucleotide Pyrophosphatase/Phosphodiesterase FamilyMember 4, E-NPP 4, NPP-4) - 126341 from USBiological Life Science
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Anti -ENPP4, ID (ENPP4, KIAA0879, NPP4, Ectonucleotide pyrophosphatase/phosphodiesterasefamily member 4) - 035083 from USBiological Life Science
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Anti -ENPP4, ID (ENPP4, KIAA0879, NPP4, Ectonucleotide pyrophosphatase/phosphodiesterasefamily member 4) (AP) - 035083-AP from USBiological Life Science
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Anti -ENPP4, ID (ENPP4, KIAA0879, NPP4, Ectonucleotide pyrophosphatase/phosphodiesterasefamily member 4) (APC) - 035083-APC from USBiological Life Science
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Anti -ENPP4, ID (ENPP4, KIAA0879, NPP4, Ectonucleotide pyrophosphatase/phosphodiesterasefamily member 4) (Azide free) (HRP) - 035083-HRP from USBiological Life Science
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