ENPP4

Gene Symbol ENPP4
Entrez Gene 22875
Alt Symbol NPP4
Species Human
Gene Type protein-coding
Description ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
Other Description AP3A hydrolase|AP3Aase|E-NPP 4|NPP-4|bis(5'-adenosyl)-triphosphatase ENPP4|ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function)|ectonucleotide pyrophosphatase/phosphodiesterase family member 4
Swissprots Q9Y6X5 Q7L2N1 A8K5G1
Accessions CAJ78397 EAX04292 Q9Y6X5 AB020686 BAA74902 AJ420515 AK291276 BAF83965 BC018054 AAH18054 BI548305 CA433087 DA261977 DQ892332 ABM83258 DQ895537 ABM86463 NM_014936 NP_055751
Function Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269|PubMed:22995898, ECO:0000269|PubMed:24338010}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:22995898}; Single-pass type I membrane protein {ECO:0000269|PubMed:22995898}.
Tissue Specificity Expressed on the surface of vascular endothelia. {ECO:0000269|PubMed:22995898}.
Top Pathways Purine metabolism

NPP4 CRISPR/Cas9 KO Plasmid (h) - sc-409823 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPP4 HDR Plasmid (h) - sc-409823-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPP4 Double Nickase Plasmid (h) - sc-409823-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPP4 Double Nickase Plasmid (h2) - sc-409823-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPP4 CRISPR Activation Plasmid (h) - sc-409823-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPP4 CRISPR Activation Plasmid (h2) - sc-409823-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPP4 Lentiviral Activation Particles (h) - sc-409823-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPP4 Lentiviral Activation Particles (h2) - sc-409823-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPP4 siRNA (h) - sc-95266 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NPP4 shRNA Plasmid (h) - sc-95266-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NPP4 shRNA (h) Lentiviral Particles - sc-95266-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU012681 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0170 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0171 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0169 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN7883 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7883 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ENPP4 siRNA (Human) - CRH7832 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ENPP4 - MBS8215207 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ENPP4 (NM_014936.4) - SHH285949 from Creative biogene

Category siRNA
Species Reactivities Human

Human ENPP4 siRNA - orb268334 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ENPP4 shRNA Plasmid (Human) - CHH7832 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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