Gene Symbol | ENPP4 |
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Entrez Gene | 22875 |
Alt Symbol | NPP4 |
Species | Human |
Gene Type | protein-coding |
Description | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) |
Other Description | AP3A hydrolase|AP3Aase|E-NPP 4|NPP-4|bis(5'-adenosyl)-triphosphatase ENPP4|ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function)|ectonucleotide pyrophosphatase/phosphodiesterase family member 4 |
Swissprots | Q9Y6X5 Q7L2N1 A8K5G1 |
Accessions | CAJ78397 EAX04292 Q9Y6X5 AB020686 BAA74902 AJ420515 AK291276 BAF83965 BC018054 AAH18054 BI548305 CA433087 DA261977 DQ892332 ABM83258 DQ895537 ABM86463 NM_014936 NP_055751 |
Function | Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269|PubMed:22995898, ECO:0000269|PubMed:24338010}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:22995898}; Single-pass type I membrane protein {ECO:0000269|PubMed:22995898}. |
Tissue Specificity | Expressed on the surface of vascular endothelia. {ECO:0000269|PubMed:22995898}. |
Top Pathways | Purine metabolism |
NPP4 CRISPR/Cas9 KO Plasmid (h) - sc-409823 from Santa Cruz Biotechnology
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NPP4 HDR Plasmid (h) - sc-409823-HDR from Santa Cruz Biotechnology
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NPP4 Double Nickase Plasmid (h) - sc-409823-NIC from Santa Cruz Biotechnology
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NPP4 Double Nickase Plasmid (h2) - sc-409823-NIC-2 from Santa Cruz Biotechnology
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NPP4 CRISPR Activation Plasmid (h) - sc-409823-ACT from Santa Cruz Biotechnology
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NPP4 CRISPR Activation Plasmid (h2) - sc-409823-ACT-2 from Santa Cruz Biotechnology
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NPP4 Lentiviral Activation Particles (h) - sc-409823-LAC from Santa Cruz Biotechnology
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NPP4 Lentiviral Activation Particles (h2) - sc-409823-LAC-2 from Santa Cruz Biotechnology
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NPP4 siRNA (h) - sc-95266 from Santa Cruz Biotechnology
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NPP4 shRNA Plasmid (h) - sc-95266-SH from Santa Cruz Biotechnology
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NPP4 shRNA (h) Lentiviral Particles - sc-95266-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU012681 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0170 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0171 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0169 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7883 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7883 from Sigma-Aldrich
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ENPP4 siRNA (Human) - CRH7832 from Cohesion Biosciences
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ENPP4 - MBS8215207 from MyBioSource
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shRNA set against Human ENPP4 (NM_014936.4) - SHH285949 from Creative biogene
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Human ENPP4 siRNA - orb268334 from Biorbyt
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ENPP4 shRNA Plasmid (Human) - CHH7832 from Cohesion Biosciences
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