Gene Symbol | ENPP4 |
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Entrez Gene | 22875 |
Alt Symbol | NPP4 |
Species | Human |
Gene Type | protein-coding |
Description | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) |
Other Description | AP3A hydrolase|AP3Aase|E-NPP 4|NPP-4|bis(5'-adenosyl)-triphosphatase ENPP4|ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function)|ectonucleotide pyrophosphatase/phosphodiesterase family member 4 |
Swissprots | Q9Y6X5 Q7L2N1 A8K5G1 |
Accessions | CAJ78397 EAX04292 Q9Y6X5 AB020686 BAA74902 AJ420515 AK291276 BAF83965 BC018054 AAH18054 BI548305 CA433087 DA261977 DQ892332 ABM83258 DQ895537 ABM86463 NM_014936 NP_055751 |
Function | Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269|PubMed:22995898, ECO:0000269|PubMed:24338010}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:22995898}; Single-pass type I membrane protein {ECO:0000269|PubMed:22995898}. |
Tissue Specificity | Expressed on the surface of vascular endothelia. {ECO:0000269|PubMed:22995898}. |
Top Pathways | Purine metabolism |
Human ENPP4 full length protein - ab161455 from Abcam
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ENPP4 Antibody Blocking Peptide - LS-E5650 from LifeSpan Bioscience
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ENPP4 Recombinant Protein - H00022875-P01 from Novus Biologicals
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ENPP4-Antibody-Center-Blocking-Peptide - BP18179c from Abgent, a WuXi AppTec company
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ENPP4 - H00022875-P01-10 from Acris Antibodies
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ENPP4 - H00022875-P01-25 from Acris Antibodies
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ENPP4 fusion protein - Ag11192 from Proteintech Group
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Recombinant Human ENPP4, GST-tagged - ENPP4-12461H from Creative Biomart
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ENPP4 Recombinant Protein Antigen - NBP1-81466PEP from Novus Biologicals
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 4 (ENPP4), Recombinant Protein - MBS1414572 from MyBioSource
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