CAMK1

Gene Symbol CAMK1
Entrez Gene 8536
Alt Symbol CAMKI
Species Human
Gene Type protein-coding
Description calcium/calmodulin-dependent protein kinase I
Other Description caM kinase I alpha|caM-KI|caMKI-alpha|calcium/calmodulin-dependent protein kinase type 1
Swissprots Q3KPF6 Q14012
Accessions ACA05961 EAW63989 EAW63990 EAW63991 EAW63992 EAW63993 Q14012 AA724193 AB209395 BAD92632 AB451277 BAG70091 AB451407 BAG70221 AK314917 BAG37428 BC106754 AAI06755 BC106755 AAI06756 BI546222 DN990042 EU832761 ACE87772 GQ129304 ACT64438 L41816 AAA99458 XM_005265516 XP_005265573 XM_005265517 XP_005265574 XR_940505 NM_003656 NP_003647
Function Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on '
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}.
Tissue Specificity Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. {ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:17056143}.
Top Pathways Oxytocin signaling pathway

CaMKI (H-125) - sc-33165 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CaMKI (H-125): sc-33165. Immunofluorescence staining of normal mouse intestine frozen section showing perinuclear staining.

CaMKI (D-9) - sc-377418 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKI (D-9): sc-377418. Western blot analysis of CaMKI expression in non-transfected: sc-117752 (A) and human CaMKI transfected: sc-177014 (B) 293T whole cell lysates.

CaMKI (H-8) - sc-137225 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKI (H-8): sc-137225. Western blot analysis of CaMKI expression in non-transfected: sc-117752 (A) and mouse CaMKI transfected: sc-118979 (B) 293T whole cell lysates.

CaMKI (M-20) - sc-1544 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CaMKI (M-20): sc-1544. Western blot analysis of CaMKI expression in rat brain (A) and mouse brain (B) tissue extracts.

CaMKI (C-19) - sc-1543 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CaMKI (C-19): sc-1543. Western blot analysis of CaMKI expression in non-transfected: sc-117752 (A) and mouse CaMKI transfected: sc-118979 (B) 293T whole cell lysates.

Anti-CaMKI (phospho T177) antibody - ab62215 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells, using ab62215 (1/500 - 1/1000) staining CaMKI; in the presence and absence of immunizing peptide.

Anti-CaMKI antibody - ab3551 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CaMKI antibody (ab3551) at 2 µg/ml + Cell lysate prepared from AtT20 cells

Anti-CaMKI antibody - ab15810 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CaMKI antibody - ab62683 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62683 at 1/50 - 1/100 dilution staining CaMKI in human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-CaMKI antibody - ab56380 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CaMKI antibody [5H8] - ab78917 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5H8
All lanes : Anti-CaMKI antibody [5H8] (ab78917) at 1/1000 dilutionLane 1 : recombinant CaMKILane 2 : recombinant CAMK1 betaLane 3 : recombinant CAMK1 gammaLane 4 : recombinant CAMK1 deltaLane 5 : recombinant CAMK2 alphaLane 6 : recombinant CAMK2 betaLane 7 : recombinant CAMK2 gammaLane 8 : recombinant CAMK4 Lysates/proteins at 0.02 µg per lane.

Anti-CaMKI antibody [EP2218Y] - ab62374 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2218Y
Anti-CaMKI antibody [EP2218Y] (ab62374) at 1/20000 dilution + SH-SY5Y cell lysate at 10 µgSecondarygoat anti-rabbit, HRP labeled, at 1/2000 dilution

Anti-CaMKI antibody [EPR2217Y] - ab68234 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2217Y
All lanes : Anti-CaMKI antibody [EPR2217Y] (ab68234) at 1/5000 dilutionLane 1 : SH-SY5Y lysateLane 2 : human brain tissue lysateLane 3 : mouse brain tissue lysateLane 4 : rat brain tissue lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CaMKI antibody - Carboxyterminal end - ab38002 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CaMKI antibody - Carboxyterminal end (ab38002) at 1/100 dilution + NCIH460 cell lysate.developed using the ECL technique

Anti-CAMK1 / CAMKI Antibody (C-Terminus) - LS-C137148 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMK1 / CAMKI Antibody (aa143-192) - LS-C117836 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma tissue, using CaMK1-alpha (Ab-177) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-CAMK1 / CAMKI Antibody (C-Terminus, AP) - LS-C218724 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMK1 / CAMKI Antibody (C-Terminus, APC) - LS-C218725 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMK1 / CAMKI Antibody (Ser173) - LS-C191912 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (IHC) analysis of CaMKI alpha (S173) pAb in paraffin-embedded human breast cancer tissue.

Anti-CAMK1 / CAMKI Antibody (C-Terminus, Biotin) - LS-C218726 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMK1 / CAMKI Antibody (N-Terminus, clone EPR2217Y) - LS-C105301 from LifeSpan Bioscience

Prices $480.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2217Y
IHC of paraffin-embedded human kidney using anti-CaMK1 antibody (LS-C105301).

Anti-CAMK4 / CaMK IV Antibody (Val192/196) - LS-C176393 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of CaMK4 (V192/196) pAb in paraffin-embedded human breast tissue.

Anti-CAMK1 / CAMKI Antibody (C-Terminus, FITC) - LS-C218727 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMK1 / CAMKI Antibody (C-Terminus, Azide-free, HRP) - LS-C218728 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMK1 / CAMKI Antibody (C-Terminus, PE) - LS-C218730 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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