CAMK1

Gene Symbol	CAMK1
Entrez Gene	8536
Alt Symbol	CAMKI
Species	Human
Gene Type	protein-coding
Description	calcium/calmodulin-dependent protein kinase I
Other Description	caM kinase I alpha|caM-KI|caMKI-alpha|calcium/calmodulin-dependent protein kinase type 1
Swissprots	Q3KPF6 Q14012
Accessions	ACA05961 EAW63989 EAW63990 EAW63991 EAW63992 EAW63993 Q14012 AA724193 AB209395 BAD92632 AB451277 BAG70091 AB451407 BAG70221 AK314917 BAG37428 BC106754 AAI06755 BC106755 AAI06756 BI546222 DN990042 EU832761 ACE87772 GQ129304 ACT64438 L41816 AAA99458 XM_005265516 XP_005265573 XM_005265517 XP_005265574 XR_940505 NM_003656 NP_003647
Function	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on '
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}.
Tissue Specificity	Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. {ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:17056143}.
Top Pathways	Oxytocin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse CaMKI full length protein - ab51398 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source E. coli Species Mouse

CaMKI peptide - ab5015 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human CaMKI full length protein - ab160080 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CaMKI protein fragment - ab160081 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CAMK1 / CAMKI Antibody Blocking Peptide - LS-E8766 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CAMK1 / CAMKI Antibody Blocking Peptide - LS-E23276 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CaM Kinase I Protein - H00008536-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CaM Kinase I Protein - H00008536-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CaM Kinase I Recombinant Protein - P4213 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

CaM Kinase I Recombinant Protein - P4197 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant CaM Kinase I Protein - NBP1-99887 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

CaMKI Peptide - P2374 from Novus Biologicals Category Peptide Species Human

CAMK1-Antibody-C-term-Blocking-Peptide - BP7205a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CAMK1 protein - orb84144 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

CAMK1 - H00008536-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CAMK1 - H00008536-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CAMK1 - H00008536-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CAMK1 - H00008536-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CAMK1 - P4197 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

CAMK1 - P4213 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

CAMK1 - P5690 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

CAMK1 Control Peptide - SP5224CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

CAMK1 fusion protein - Ag19449 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CAMK1 fusion protein - ag19473 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CAMK1, His tagged - CAMK1-963H from Creative Biomart Category Protein Source E. coli Species Human

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