Gene Symbol | CAMK1 |
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Entrez Gene | 8536 |
Alt Symbol | CAMKI |
Species | Human |
Gene Type | protein-coding |
Description | calcium/calmodulin-dependent protein kinase I |
Other Description | caM kinase I alpha|caM-KI|caMKI-alpha|calcium/calmodulin-dependent protein kinase type 1 |
Swissprots | Q3KPF6 Q14012 |
Accessions | ACA05961 EAW63989 EAW63990 EAW63991 EAW63992 EAW63993 Q14012 AA724193 AB209395 BAD92632 AB451277 BAG70091 AB451407 BAG70221 AK314917 BAG37428 BC106754 AAI06755 BC106755 AAI06756 BI546222 DN990042 EU832761 ACE87772 GQ129304 ACT64438 L41816 AAA99458 XM_005265516 XP_005265573 XM_005265517 XP_005265574 XR_940505 NM_003656 NP_003647 |
Function | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on ' |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}. |
Tissue Specificity | Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. {ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:17056143}. |
Top Pathways | Oxytocin signaling pathway |
Active mouse CaMKI full length protein - ab51398 from Abcam
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CaMKI peptide - ab5015 from Abcam
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Human CaMKI full length protein - ab160080 from Abcam
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Human CaMKI protein fragment - ab160081 from Abcam
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CAMK1 / CAMKI Antibody Blocking Peptide - LS-E8766 from LifeSpan Bioscience
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CAMK1 / CAMKI Antibody Blocking Peptide - LS-E23276 from LifeSpan Bioscience
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Recombinant Human CaM Kinase I Protein - H00008536-P01 from Novus Biologicals
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Recombinant Human CaM Kinase I Protein - H00008536-Q01 from Novus Biologicals
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CaM Kinase I Recombinant Protein - P4213 from Novus Biologicals
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CaM Kinase I Recombinant Protein - P4197 from Novus Biologicals
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Recombinant CaM Kinase I Protein - NBP1-99887 from Novus Biologicals
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CaMKI Peptide - P2374 from Novus Biologicals
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CAMK1-Antibody-C-term-Blocking-Peptide - BP7205a from Abgent, a WuXi AppTec company
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Human CAMK1 protein - orb84144 from Biorbyt
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CAMK1 - H00008536-P01-10 from Acris Antibodies
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CAMK1 - H00008536-P01-25 from Acris Antibodies
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CAMK1 - H00008536-Q01-10 from Acris Antibodies
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CAMK1 - H00008536-Q01-25 from Acris Antibodies
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CAMK1 - P4197 from Acris Antibodies
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CAMK1 - P4213 from Acris Antibodies
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CAMK1 - P5690 from Acris Antibodies
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CAMK1 Control Peptide - SP5224CP from Acris Antibodies
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CAMK1 fusion protein - Ag19449 from Proteintech Group
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CAMK1 fusion protein - ag19473 from Proteintech Group
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Recombinant Human CAMK1, His tagged - CAMK1-963H from Creative Biomart
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