CAMK1

Gene Symbol CAMK1
Entrez Gene 8536
Alt Symbol CAMKI
Species Human
Gene Type protein-coding
Description calcium/calmodulin-dependent protein kinase I
Other Description caM kinase I alpha|caM-KI|caMKI-alpha|calcium/calmodulin-dependent protein kinase type 1
Swissprots Q3KPF6 Q14012
Accessions ACA05961 EAW63989 EAW63990 EAW63991 EAW63992 EAW63993 Q14012 AA724193 AB209395 BAD92632 AB451277 BAG70091 AB451407 BAG70221 AK314917 BAG37428 BC106754 AAI06755 BC106755 AAI06756 BI546222 DN990042 EU832761 ACE87772 GQ129304 ACT64438 L41816 AAA99458 XM_005265516 XP_005265573 XM_005265517 XP_005265574 XR_940505 NM_003656 NP_003647
Function Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on '
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}.
Tissue Specificity Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. {ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:17056143}.
Top Pathways Oxytocin signaling pathway

Active mouse CaMKI full length protein - ab51398 from Abcam

Category Protein
Prices $302.00
Sizes 10 µg
Source E. coli
Species Mouse
Purity determined to be > 90% by densitometry. Molecular weight 70 kDa.

CaMKI peptide - ab5015 from Abcam

Category Peptide
Prices $181.00
Sizes 50 µg

Human CaMKI full length protein - ab160080 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab160080 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human CaMKI protein fragment - ab160081 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab160081 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CAMK1 / CAMKI Antibody Blocking Peptide - LS-E8766 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CAMK1 / CAMKI Antibody Blocking Peptide - LS-E23276 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human CaM Kinase I Protein - H00008536-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human CaM Kinase I Protein - H00008536-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CaM Kinase I Recombinant Protein - P4213 from Novus Biologicals

Category Protein
Prices $549.00
Sizes 5 µg
Species Human

CaM Kinase I Recombinant Protein - P4197 from Novus Biologicals

Category Protein
Prices $549.00
Sizes 5 µg
Species Human

Recombinant CaM Kinase I Protein - NBP1-99887 from Novus Biologicals

Category Protein
Prices $295.00
Sizes 5 µg
Source Baculovirus (Sf9 insect cells)

CaMKI Peptide - P2374 from Novus Biologicals

Category Peptide
Species Human

CAMK1-Antibody-C-term-Blocking-Peptide - BP7205a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Human CAMK1 protein - orb84144 from Biorbyt

Category Protein
Prices $323.00, $646.00
Sizes 20 μg, 100 μg
Source E. coli
Species Human

CAMK1 - H00008536-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CAMK1 - H00008536-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CAMK1 - H00008536-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CAMK1 - H00008536-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CAMK1 - P4197 from Acris Antibodies

Category Protein
Prices $670.00
Sizes 5 µg
Species Human

CAMK1 - P4213 from Acris Antibodies

Category Protein
Prices $670.00
Sizes 5 µg
Species Human

CAMK1 - P5690 from Acris Antibodies

Category Protein
Prices $840.00
Sizes 5 µg
Species Human

CAMK1 Control Peptide - SP5224CP from Acris Antibodies

Category Peptide
Prices $205.00
Sizes 50 µg

CAMK1 fusion protein - Ag19449 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

CAMK1 fusion protein - ag19473 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant Human CAMK1, His tagged - CAMK1-963H from Creative Biomart

Category Protein
Source E. coli
Species Human
Search more