CAMK1
| Gene Symbol | CAMK1 |
|---|---|
| Entrez Gene | 8536 |
| Alt Symbol | CAMKI |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium/calmodulin-dependent protein kinase I |
| Other Description | caM kinase I alpha|caM-KI|caMKI-alpha|calcium/calmodulin-dependent protein kinase type 1 |
| Swissprots | Q3KPF6 Q14012 |
| Accessions | ACA05961 EAW63989 EAW63990 EAW63991 EAW63992 EAW63993 Q14012 AA724193 AB209395 BAD92632 AB451277 BAG70091 AB451407 BAG70221 AK314917 BAG37428 BC106754 AAI06755 BC106755 AAI06756 BI546222 DN990042 EU832761 ACE87772 GQ129304 ACT64438 L41816 AAA99458 XM_005265516 XP_005265573 XM_005265517 XP_005265574 XR_940505 NM_003656 NP_003647 |
| Function | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on ' |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. {ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:17056143}. |
| Top Pathways | Oxytocin signaling pathway |
CaMKI CRISPR/Cas9 KO Plasmid (h) - sc-401136 from Santa Cruz Biotechnology
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CaMKI HDR Plasmid (h) - sc-401136-HDR from Santa Cruz Biotechnology
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CaMKI Double Nickase Plasmid (h) - sc-401136-NIC from Santa Cruz Biotechnology
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CaMKI Double Nickase Plasmid (h2) - sc-401136-NIC-2 from Santa Cruz Biotechnology
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CaMKI CRISPR Activation Plasmid (h) - sc-401136-ACT from Santa Cruz Biotechnology
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CaMKI CRISPR Activation Plasmid (h2) - sc-401136-ACT-2 from Santa Cruz Biotechnology
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CaMKI Lentiviral Activation Particles (h) - sc-401136-LAC from Santa Cruz Biotechnology
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CaMKI Lentiviral Activation Particles (h2) - sc-401136-LAC-2 from Santa Cruz Biotechnology
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CaMKI siRNA (h) - sc-38947 from Santa Cruz Biotechnology
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CaMKI shRNA Plasmid (h) - sc-38947-SH from Santa Cruz Biotechnology
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CaMKI shRNA (h) Lentiviral Particles - sc-38947-V from Santa Cruz Biotechnology
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CaM Kinase I RNAi - H00008536-R02 from Novus Biologicals
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MISSION® esiRNA - EHU039251 from Sigma-Aldrich
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MISSION® siRNA - SIHK0235 from Sigma-Aldrich
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MISSION® siRNA - SIHK0236 from Sigma-Aldrich
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MISSION® siRNA - SIHK0234 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5312 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5312 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00837 from Sigma-Aldrich
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CAMK1 siRNA (Human) - CRH5607 from Cohesion Biosciences
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CAMK1 - MBS8226729 from MyBioSource
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CaMKI CRISPR/Cas9 KO Plasmid (h2) - sc-401136-KO-2 from Santa Cruz Biotechnology
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CaMKI HDR Plasmid (h2) - sc-401136-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CAMK1 (NM_003656.4) - SHH253953 from Creative biogene
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Human CAMK1 siRNA - orb266109 from Biorbyt
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