Gene Symbol | CAMK1 |
---|---|
Entrez Gene | 8536 |
Alt Symbol | CAMKI |
Species | Human |
Gene Type | protein-coding |
Description | calcium/calmodulin-dependent protein kinase I |
Other Description | caM kinase I alpha|caM-KI|caMKI-alpha|calcium/calmodulin-dependent protein kinase type 1 |
Swissprots | Q3KPF6 Q14012 |
Accessions | ACA05961 EAW63989 EAW63990 EAW63991 EAW63992 EAW63993 Q14012 AA724193 AB209395 BAD92632 AB451277 BAG70091 AB451407 BAG70221 AK314917 BAG37428 BC106754 AAI06755 BC106755 AAI06756 BI546222 DN990042 EU832761 ACE87772 GQ129304 ACT64438 L41816 AAA99458 XM_005265516 XP_005265573 XM_005265517 XP_005265574 XR_940505 NM_003656 NP_003647 |
Function | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on ' |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}. |
Tissue Specificity | Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. {ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:17056143}. |
Top Pathways | Oxytocin signaling pathway |
Mouse/Human/Rat Phospho-CAMK1 / CAMKI (Thr177) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1323 from LifeSpan Bioscience
|
||||||||
Mouse/Human/Rat CAMK1 / CAMKI ELISA Kit (Cell-Based ELISA) - LS-F1845 from LifeSpan Bioscience
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), Human, ELISA Kit - E01C1331 from ARP American Research Products
|
||||||||
CaMK1-alpha Colorimetric Cell-Based ELISA Kit - CB5091 from Assay Biotechnology
|
||||||||
CaMK1-alpha (Phospho-Thr177) Colorimetric Cell-Based ELISA Kit - CBP1328 from Assay Biotechnology
|
||||||||
Calcium/calmodulin dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7204794 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7222571 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7243320 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7216954 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7239998 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7236459 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7229807 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7231600 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7219097 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7216101 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7217639 from MyBioSource
|
||||||||
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1), ELISA Kit - MBS7205865 from MyBioSource
|
||||||||
Human CAMK1 ELISA Kit - E006084 from Biobool
|
||||||||