| Gene Symbol |
CAMK1
|
| Entrez Gene |
8536
|
| Alt Symbol |
CAMKI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium/calmodulin-dependent protein kinase I
|
| Other Description |
caM kinase I alpha|caM-KI|caMKI-alpha|calcium/calmodulin-dependent protein kinase type 1
|
| Swissprots |
Q3KPF6 Q14012
|
| Accessions |
ACA05961 EAW63989 EAW63990 EAW63991 EAW63992 EAW63993 Q14012 AA724193 AB209395 BAD92632 AB451277 BAG70091 AB451407 BAG70221 AK314917 BAG37428 BC106754 AAI06755 BC106755 AAI06756 BI546222 DN990042 EU832761 ACE87772 GQ129304 ACT64438 L41816 AAA99458 XM_005265516 XP_005265573 XM_005265517 XP_005265574 XR_940505 NM_003656 NP_003647
|
| Function |
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on '
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. {ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:17056143}.
|
| Top Pathways |
Oxytocin signaling pathway
|
