Gene Symbol | IFITM2 |
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Entrez Gene | 10581 |
Alt Symbol | 1-8D, DSPA2c |
Species | Human |
Gene Type | protein-coding |
Description | interferon induced transmembrane protein 2 |
Other Description | dispanin subfamily A member 2c|interferon-induced transmembrane protein 2|interferon-inducible protein 1-8D |
Swissprots | Q6FH82 Q01629 Q96DA8 |
Accessions | CAK32181 EAW61220 EAW61221 Q01629 BC009696 AAH09696 BG164993 BG257141 BT009859 AAP88861 CR456894 CAG33175 CR541874 CAG46672 DQ891667 ABM82593 DQ894615 ABM85541 X02490 CAA26321 X57351 CAA40625 NM_006435 NP_006426 |
Function | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
IFITM2 Antibody - 13530 from Cell Signaling Technology
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IFITM2 (A-6) - sc-373676 from Santa Cruz Biotechnology
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IFITM2 (E-19) - sc-50902 from Santa Cruz Biotechnology
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IFITM2/3 (N-14) - sc-131568 from Santa Cruz Biotechnology
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Anti-IFITM2 antibody - ab88415 from Abcam
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Anti-IFITM2 antibody - ab68506 from Abcam
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Anti-IFITM2 antibody - ab168617 from Abcam
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Anti-IFITM2 antibody - N-terminal - ab175124 from Abcam
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Anti-IFITM2 Antibody (aa6-35, AP) - LS-C215210 from LifeSpan Bioscience
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Anti-IFITM2 Antibody (aa6-35, APC) - LS-C215211 from LifeSpan Bioscience
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Anti-IFITM2 Antibody (aa6-35, Biotin) - LS-C215212 from LifeSpan Bioscience
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Anti-IFITM2 Antibody (aa6-35, FITC) - LS-C215213 from LifeSpan Bioscience
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Anti-IFITM2 Antibody - LS-C308390 from LifeSpan Bioscience
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Anti-IFITM2 Antibody (aa6-35, Azide-free, HRP) - LS-C215214 from LifeSpan Bioscience
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Anti-IFITM2 Antibody (aa6-35, PE) - LS-C215215 from LifeSpan Bioscience
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Anti-IFITM2 Antibody - LS-C310704 from LifeSpan Bioscience
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Anti-IFITM2 Antibody (aa1-59) - LS-C308392 from LifeSpan Bioscience
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Anti-IFITM2 Antibody (aa6-35) - LS-C322156 from LifeSpan Bioscience
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Anti-IFITM2 Antibody (N-Terminus) - LS-C345446 from LifeSpan Bioscience
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Anti-IFITM2 Antibody (aa1-30) IHC-plus⢠- LS-B9342 from LifeSpan Bioscience
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IFITM2 Antibody - H00010581-B01P from Novus Biologicals
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IFITM2 Antibody - H00010581-D01P from Novus Biologicals
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IFITM2 Antibody (1F2) - H00010581-M14 from Novus Biologicals
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IFITM2 Polyclonal Antibody - bs-15517R from Bioss
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Anti-IFITM2 antibody produced in mouse - SAB1400394 from Sigma-Aldrich
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