Gene Symbol | IFITM2 |
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Entrez Gene | 10581 |
Alt Symbol | 1-8D, DSPA2c |
Species | Human |
Gene Type | protein-coding |
Description | interferon induced transmembrane protein 2 |
Other Description | dispanin subfamily A member 2c|interferon-induced transmembrane protein 2|interferon-inducible protein 1-8D |
Swissprots | Q6FH82 Q01629 Q96DA8 |
Accessions | CAK32181 EAW61220 EAW61221 Q01629 BC009696 AAH09696 BG164993 BG257141 BT009859 AAP88861 CR456894 CAG33175 CR541874 CAG46672 DQ891667 ABM82593 DQ894615 ABM85541 X02490 CAA26321 X57351 CAA40625 NM_006435 NP_006426 |
Function | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
IFITM2 CRISPR/Cas9 KO Plasmid (h) - sc-403889 from Santa Cruz Biotechnology
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IFITM2 HDR Plasmid (h) - sc-403889-HDR from Santa Cruz Biotechnology
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IFITM2 Double Nickase Plasmid (h) - sc-403889-NIC from Santa Cruz Biotechnology
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IFITM2 Double Nickase Plasmid (h2) - sc-403889-NIC-2 from Santa Cruz Biotechnology
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IFITM2 CRISPR Activation Plasmid (h) - sc-403889-ACT from Santa Cruz Biotechnology
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IFITM2 CRISPR Activation Plasmid (h2) - sc-403889-ACT-2 from Santa Cruz Biotechnology
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IFITM2 Lentiviral Activation Particles (h) - sc-403889-LAC from Santa Cruz Biotechnology
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IFITM2 Lentiviral Activation Particles (h2) - sc-403889-LAC-2 from Santa Cruz Biotechnology
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IFITM2 siRNA (h) - sc-96760 from Santa Cruz Biotechnology
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IFITM2 shRNA Plasmid (h) - sc-96760-SH from Santa Cruz Biotechnology
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IFITM2 shRNA (h) Lentiviral Particles - sc-96760-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU109931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10471 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01607 from Sigma-Aldrich
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IFITM2 siRNA (Human) - CRH7201 from Cohesion Biosciences
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IFITM2 - MBS8230773 from MyBioSource
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shRNA set against Human IFITM2 (NM_006435.2) - SHH316961 from Creative biogene
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shRNA set against Human IFITM2(NM_006435.2) - SHL166260 from Creative biogene
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Human IFITM2 siRNA - orb267703 from Biorbyt
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IFITM2 shRNA Plasmid (Human) - CHH7201 from Cohesion Biosciences
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IFITM2 miRNA 3'UTR clone - MiUTR1H-04807 from Creative biogene
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