FCN1

Gene Symbol	FCN1
Entrez Gene	2219
Alt Symbol	FCNM
Species	Human
Gene Type	protein-coding
Description	ficolin (collagen/fibrinogen domain containing) 1
Other Description	M-ficolin|collagen/fibrinogen domain-containing protein 1|ficolin (collagen/fibrinogen domain-containing) 1|ficolin-1|ficolin-A|ficolin-alpha
Swissprots	Q5VYV5 Q92596 O00602
Accessions	BAA09707 CBX51283 EAW88137 EAW88138 EAW88139 EAW88140 O00602 AK314867 BAG37382 BC020635 AAH20635 BG482630 CR749452 CAH18289 D83920 BAA12120 DQ891426 ABM82352 DQ894436 ABM85362 NM_002003 NP_001994
Function	Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. {ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:21037097}.
Subcellular Location	Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface.
Tissue Specificity	Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes. {ECO:0000269|PubMed:20400674}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FCN1 / Ficolin-1 ELISA Kit (Sandwich ELISA) - LS-F2919 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 20 pg/ml Range 0.78-50 ng/ml

Mouse FCN1 / Ficolin-1 ELISA Kit (Sandwich ELISA) - LS-F4343 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.78-50 ng/ml

Human FCN1 / Ficolin-1 ELISA Kit (Sandwich ELISA) - LS-F6424 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.066 ng/ml Range 0.78-50 ng/ml

Rat FCN1 / Ficolin-1 ELISA Kit (Sandwich ELISA) - LS-F8168 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.33 ng/ml Range 0.78-50 ng/ml

Ficolin 1, FCN1, Human, ELISA Kit - E-EL-H0378 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Ficolin 1 (FCN1), Human, ELISA Kit - SEA786Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.055ng/mL Range 0.156-10ng/mL

Ficolin-1 (FCN1), Human, ELISA Kit - CSB-EL008550HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Ficolin-1 (FCN1), Human, ELISA Kit - E01F0364 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Ficolin-1, FCN1, Human, ELISA Kit - E1506h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Ficolin 1, FCN1, Rabbit, ELISA Kit - E-EL-RB0942 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ficolin 1, FCN1, Chicken, ELISA Kit - E-EL-Ch1412 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ficolin 1, FCN1, Porcine, ELISA Kit - E-EL-P0421 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ficolin 1, FCN1, Sheep, ELISA Kit - E-EL-S0629 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Immunoglobulin M, IgM, Guinea Pig, ELISA Kit - E-EL-GP1142 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 3.75 Range 6.25-400ng/mL

Ficolin 1, FCN1, Monkey, ELISA Kit - E-EL-MK1844 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

FCN1 (Human) Matched Antibody Pair - H00002219-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

FCN1 (Human) Matched Antibody Pair - H00002219-AP22 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Ficolin 1 (FCN1), ELISA Kit - MBS2020932 from MyBioSource Category ELISA Kit Prices $350.00, $525.00, $715.00, $2,915.00, $5,315.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.056ng/mL. Range 0.156-10ng/mL

Ficolin 1 (FCN1), ELISA Kit - MBS2019424 from MyBioSource Category ELISA Kit Prices $370.00, $550.00, $750.00, $3,065.00, $5,550.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.33ng/mL. Range 0.781-50ng/mL

Ficolin 1 (FCN1), ELISA Kit - MBS2020259 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.055ng/mL. Range 0.156-10ng/mL

Ficolin 1 (FCN1), ELISA Kit - MBS7249078 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ficolin 1 (FCN1), ELISA Kit - MBS9308869 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

IgM, ELISA Kit - MBS2512852 from MyBioSource Category ELISA Kit Prices $400.00, $475.00, $1,975.00, $3,480.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Guinea pig IgM is 3.75ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 6.25-400ng/mL

Human FCN1(Ficolin 1) ELISA Kit - E-EL-H0378 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human FCN1 (Ficolin 1) CLIA Kit - E-CL-H0308 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

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