FCN1

Gene Symbol	FCN1
Entrez Gene	2219
Alt Symbol	FCNM
Species	Human
Gene Type	protein-coding
Description	ficolin (collagen/fibrinogen domain containing) 1
Other Description	M-ficolin|collagen/fibrinogen domain-containing protein 1|ficolin (collagen/fibrinogen domain-containing) 1|ficolin-1|ficolin-A|ficolin-alpha
Swissprots	Q5VYV5 Q92596 O00602
Accessions	BAA09707 CBX51283 EAW88137 EAW88138 EAW88139 EAW88140 O00602 AK314867 BAG37382 BC020635 AAH20635 BG482630 CR749452 CAH18289 D83920 BAA12120 DQ891426 ABM82352 DQ894436 ABM85362 NM_002003 NP_001994
Function	Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. {ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:21037097}.
Subcellular Location	Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface.
Tissue Specificity	Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes. {ECO:0000269|PubMed:20400674}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FCN1 full length protein - ab158424 from Abcam Category Protein Source Wheat germ Species Human

Human FCN1 protein fragment - ab158425 from Abcam Category Protein Source Wheat germ Species Human

FCN1 / Ficolin-1 Antibody Blocking Peptide - LS-E4665 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FCN1 / Ficolin-1 Antibody Blocking Peptide - LS-E19669 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Ficolin-1 Protein - H00002219-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Ficolin-1 Protein - H00002219-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FCN1-Antibody-C-term-Blocking-Peptide - BP17029b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Ficolin-1, CF - 4209-FC-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln28-Ala326, with a C-terminal 10-His tag

FCN1 Blocking Peptide - 33R-3578 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FCN1 Blocking Peptide - 33R-3820 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Ficolin 1 Blocking Peptide - 33R-10959 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Human Ficolin 1 Protein - abx066652 from Abbexa Category Protein Source E.coli Species Human

Ficolin-1 - H00002219-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Ficolin-1 - H00002219-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Ficolin-1 - H00002219-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Ficolin-1 - H00002219-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FCN1 fusion protein - ag2444 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human FCN1, His tagged - FCN1-703H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human FCN1, His-tagged - FCN1-894H from Creative Biomart Category Protein Source NSO Cells Species Human

FCN1 - PN201570 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

Recombinant Ficolin 1 (FCN1) - RPA786Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Ficolin 1 (FCN1) - RPA786Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Ficolin 1 (FCN1) - RPA786Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Ficolin 1 (FCN1) - RPA786Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Human Ficolin-1 / Ficolin-A / FCN1 Protein (His Tag) - 10930-H08H-50 from Sino Biological Category Protein Source Human Cells Species Human

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