FCN1

Gene Symbol FCN1
Entrez Gene 2219
Alt Symbol FCNM
Species Human
Gene Type protein-coding
Description ficolin (collagen/fibrinogen domain containing) 1
Other Description M-ficolin|collagen/fibrinogen domain-containing protein 1|ficolin (collagen/fibrinogen domain-containing) 1|ficolin-1|ficolin-A|ficolin-alpha
Swissprots Q5VYV5 Q92596 O00602
Accessions BAA09707 CBX51283 EAW88137 EAW88138 EAW88139 EAW88140 O00602 AK314867 BAG37382 BC020635 AAH20635 BG482630 CR749452 CAH18289 D83920 BAA12120 DQ891426 ABM82352 DQ894436 ABM85362 NM_002003 NP_001994
Function Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. {ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:21037097}.
Subcellular Location Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface.
Tissue Specificity Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes. {ECO:0000269|PubMed:20400674}.

M-ficolin CRISPR/Cas9 KO Plasmid (h) - sc-410780 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

M-ficolin HDR Plasmid (h) - sc-410780-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

M-ficolin Double Nickase Plasmid (h) - sc-410780-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

M-ficolin Double Nickase Plasmid (h2) - sc-410780-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

M-ficolin CRISPR Activation Plasmid (h) - sc-410780-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

M-ficolin CRISPR Activation Plasmid (h2) - sc-410780-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

M-ficolin Lentiviral Activation Particles (h) - sc-410780-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

M-ficolin Lentiviral Activation Particles (h2) - sc-410780-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

M-ficolin siRNA (h) - sc-92695 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

M-ficolin shRNA Plasmid (h) - sc-92695-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

M-ficolin shRNA (h) Lentiviral Particles - sc-92695-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ficolin-1 RNAi - H00002219-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8599 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8599 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00686 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00686

FCN1 siRNA (Human) - CRH1552 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FCN1 - MBS829986 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FCN1 (NM_002003.3) - SHH293821 from Creative biogene

Category siRNA
Species Reactivities Human

Human FCN1 siRNA - orb262054 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FCN1 shRNA Plasmid (Human) - CHH1552 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FCN1 miRNA 3'UTR clone - MiUTR3H-03998 from Creative biogene

Species Reactivities Human
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